A main bottleneck in proteomics is the downstream biological analysis of highly multivariate
quantitative protein abundance data generated using mass-spectrometry-based analysis. …

Protein quantification without isotopic labels has been a long-standing interest in the
proteomics field. However, accurate and robust proteome-wide quantification with label-free …

Coral reef restoration initiatives are burgeoning in response to the need for novel management
strategies to address dramatic global declines in coral cover. However, coral restoration …

Many proteins contain disordered regions of low-sequence complexity, which cause aging-associated
diseases because they are prone to aggregate. Here, we study FUS, a prion-like …

Functional genomics efforts face tradeoffs between number of perturbations examined and
complexity of phenotypes measured. We bridge this gap with Perturb-seq, which combines …

The organization of a cell emerges from the interactions in protein networks. The interactome
is critically dependent on the strengths of interactions and the cellular abundances of the …

While coral reefs in Australia have historically been a showcase of conventional management
informed by research, recent declines in coral cover have triggered efforts to innovate and …

The human cytomegalovirus (HCMV) genome was sequenced 20 years ago. However, like
those of other complex viruses, our understanding of its protein coding potential is far from …

Absolute protein quantification using mass spectrometry (MS)-based proteomics delivers
protein concentrations or copy numbers per cell. Existing methodologies typically require a …

Elucidating the wiring diagram of the human cell is a central goal of the postgenomic era.
We combined genome engineering, confocal live-cell imaging, mass spectrometry, and data …