Understanding the pathophysiogenesis of temporal lobe epilepsy (TLE) largely rests on the
use of models of status epilepticus (SE), as in the case of the pilocarpine model. The main …

The kainic acid model of temporal lobe epilepsy has greatly contributed to the understanding
of the molecular, cellular and pharmacological mechanisms underlying epileptogenesis …

Seizures in patients presenting with mesial temporal lobe epilepsy result from the interaction
among neuronal networks in limbic structures such as the hippocampus, amygdala and …

Voltage-gated sodium channels (VGSCs) are key mediators of intrinsic neuronal and muscle
excitability. Abnormal VGSC activity is central to the pathophysiology of epileptic seizures, …

Continuous application of 4-aminopyridine (4-AP, 50 μm) to combined slices of
hippocampus–entorhinal cortex obtained from adult mice induces (1) interictal discharges that …

… The reference channel was backfilled with 150 mm NaCl and the ion-selective channel
with 100 mm KCl. In calibration solutions containing 124 mm NaCl, the electrode showed a …

High frequency oscillations (HFO) have a variety of characteristics: band-limited or broad-band,
transient burst-like phenomenon or steady-state. HFOs may be encountered under …

… Author links open overlay panel Massimo Avoli a b , Marco de Curtis c d … or shape
epileptiform synchrony (Avoli et al., 1993, Avoli et al., 1996a, Avoli et al., 1996b, Avoli et al., 1996c, …

… previously in the CA 1 region (Perreault and Avoli 1989b), where we demonstrated that this
… AND AVOLI, M. Epileptiform bursts induced by 4-aminopyridine in the rat hippocampus: …

In order to understand the pathophysiology of temporal lobe epilepsy (TLE), and thus to
develop new pharmacological treatments, in vivo animal models that present features similar to …