We previously piloted the concept of a Connectivity Map (CMap), whereby genes, drugs, and
disease states are connected by virtue of common gene-expression signatures. Here, we …

Recent genome sequencing efforts have identified millions of somatic mutations in cancer.
However, the functional impact of most variants is poorly understood. Here we characterize …

… -M cells are primed for cell transformation and have been previously used to identify genes
involved in cell transformation (16, 17). We expressed each of the 474 alleles in HA1E-M … -M …

Tumor-specific genomic information has the potential to guide therapeutic strategies and
revolutionize patient treatment. Currently, this approach is limited by an abundance of disease-…

We report the free radical scavenging activity of an Ayurvedic preparation Panchvalkala and
its individual components (stem bark of Ficus benghalensis, F. glomerata, F. religiosa, F. …

… Mean BMI at baseline was high (25.0 kg/m 2 ), ranging from 23.0 kg/m 2 in China–Pacific
to 26.9 kg/m 2 in North America. Racial variation was representative of the geographical …

Macropinocytosis has emerged as an important pathway of protein acquisition in cancer
cells, particularly in tumors with activated Ras such as pancreatic and colon cancer. …

The mitogen-activated protein kinase (MAPK) pathway is a critical effector of oncogenic RAS
signaling, and MAPK pathway inhibition may be an effective combination treatment strategy…

Objective: To carry out phytochemical analysis of Bergenia ciliata forma ligulata rhizome
and to evaluate its free radical scavenging properties. Materials and methods: Preliminary …

… Makarand Bagul was an employee of Eisai Ltd at manuscript submission. Dinesh Kumar
and Antonio Laurenza, are employees of Eisai Inc. Haichen Yang was an employee of Eisai Inc …