… a body mass index (BMI) of 30–34.9 kg m –2 carry a hazard ratio for overall mortality that is
elevated by more than 40% and at a BMI > 40 kg m –2 the relative rate increases to 100% 5 . …

… obesity as excessive fat accumulation that might impair health and is diagnosed at a BMI
≥30 kg/m 2 (ref. ). … Börjeson, M. The aetiology of obesity in children. A study of 101 twin pairs. …

Obesity increases the risk for metabolic, cardiovascular, chronic inflammatory, and several
malignant diseases and, therefore, may contribute to shortened lifespan. Adipokines are …

Genome-wide association studies (GWAS) have identified more than 100 genetic variants
contributing to BMI, a measure of body size, or waist-to-hip ratio (adjusted for BMI, WHR …

We performed fine mapping of 39 established type 2 diabetes (T2D) loci in 27,206 cases and
57,574 controls of European ancestry. We identified 49 distinct association signals at these …

Obesity is heritable and predisposes to many diseases. To understand the genetic basis of
obesity better, here we conduct a genome-wide association study and Metabochip meta-…

Background Trials comparing the effectiveness and safety of weight-loss diets are frequently
limited by short follow-up times and high dropout rates. Methods In this 2-year trial, we …

… Sex was prespecified to be male, age was prespecified to be 25 to 35 years; BMI was
prespecified to be below 27 kg/m 2 , and the training status used is defined below. All subjects …

Using genome-wide data from 253,288 individuals, we identified 697 variants at genome-wide
significance that together explained one-fifth of the heritability for adult height. By testing …

Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic
outcomes, independent of overall adiposity. To increase our understanding of the genetic …