… to three distinct phenotypes – E, M and hybrid E/M – and present a theoretical framework that
… Finally, we discuss the multiple advantages that the partial EMT or hybrid E/M phenotype …

… culturing E, hybrid E/M and M cells separately, while a majority of E and M cells retain their
phenotype, more than 70% of hybrid E/M cells transition into either E or M in 24 h, suggesting …

… spatial patterns with clusters of hybrid E/M cells, but Notch-Delta signaling leads to an
alternating arrangement of epithelial and hybrid E/M cells, similar to our previous results (5, 39) (…

… Coupling OVOL can inhibit the stemness likelihood of M and elevate that of the hybrid E/M
(partial EMT) phenotype, thereby pulling the ‘stemness window’away from the M end of ‘EMT …

Notch signaling pathway mediates cell-fate determination during embryonic development,
wound healing, and tumorigenesis. This pathway is activated when the ligand Delta or the …

Metastasis involves multiple cycles of Epithelial-to-Mesenchymal Transition (EMT) and its
reverse-MET. Cells can also undergo partial transitions to attain a hybrid epithelial/…

… /M and M phenotypes (figure 4a,b). On investigating the spatial distribution of the E, E/M and
M … , most cells in the hybrid E/M or M phenotype tend to form clusters among themselves; but …

Angiogenesis is critical during development, wound repair, and cancer progression. During
angiogenesis, some endothelial cells adopt a tip phenotype to lead the formation of new …

Neural stem cells (NSCs) in the adult mouse hippocampal dentate gyrus (DG) are mostly
quiescent, and only a few are in cell cycle at any point in time. DG NSCs become increasingly …

Hemodynamic forces and Notch signaling are both known as key regulators of arterial
remodeling and homeostasis. However, how these two factors integrate in vascular …