… were evaluated independently by two reviewers (Cassina and Donà) for exclusion of
reviews, … Finally, relevant studies for the meta-analysis were reviewed by three authors (Cassina, …

Coenzyme Q 10 (CoQ 10 ) is an essential component of eukaryotic cells and is involved in
crucial biochemical reactions such as the production of ATP in the mitochondrial respiratory …

Characterized primarily by a low body-mass index, anorexia nervosa is a complex and
serious illness 1 , affecting 0.9–4% of women and 0.3% of men 2 , 3 – 4 , with twin-based …

Epigenetics is the branch of genetics that studies the different mechanisms that influence
gene expression without direct modification of the DNA sequence. An ever-increasing amount …

Context: Clinical hyperthyroidism is not uncommon in pregnancy, with a reported prevalence
of 0.1 to 0.4%. The available antithyroid drugs are propylthiouracil and methimazole/…

Objective Findings from animal studies have suggested that leflunomide may be a human
teratogen. In the only human cohort study published to date, an increase in adverse outcomes …

Background COQ4 encodes a protein that organises the multienzyme complex for the synthesis
of coenzyme Q 10 (CoQ 10 ). A 3.9 Mb deletion of chromosome 9q34.13 was identified …

… All cases who were born with EA (ICD9 codes: 750.3) from 1981 to 2012 were reviewed
by two medical geneticists (M.Ca. and M.Cl.) and selected for this study. EA was deemed …

COQ2 (p-hydroxybenzoate polyprenyl transferase) encodes the enzyme required for the
second step of the final reaction sequence of Coenzyme Q 10 (CoQ) biosynthesis. Its mutations …

Background Multiple (epi)genetic defects affecting the expression of the imprinted genes
within the 11p15.5 chromosomal region underlie Silver–Russell (SRS) and Beckwith–…