User profiles for M. Cotten
Matthew CottenResearch Professor, Complex Adaptive Systems Initiative, Arizona State University Verified email at asu.edu Cited by 25625 |
Delivery of drugs, proteins and genes into cells using transferrin as a ligand for receptor-mediated endocytosis
Transferrin, an iron-transporting serum glycoprotein, is efficiently taken up into cells by the
process of receptor-mediated endocytosis. Transferrin receptors are found on the surface of …
process of receptor-mediated endocytosis. Transferrin receptors are found on the surface of …
HIV-2: the forgotten AIDS virus
TI de Silva, M Cotten, SL Rowland-Jones - Trends in microbiology, 2008 - cell.com
… Matthew Cotten Matthew Cotten … HIV-2 isolates are less fit than HIV-1 group M viruses
when compared by competition between viral strains in tissue culture [ …
when compared by competition between viral strains in tissue culture [ …
[HTML][HTML] Hospital outbreak of Middle East respiratory syndrome coronavirus
…, R Alhakeem, JA Al-Tawfiq, M Cotten… - … England Journal of …, 2013 - Mass Medical Soc
Background In September 2012, the World Health Organization reported the first cases of
pneumonia caused by the novel Middle East respiratory syndrome coronavirus (MERS-CoV). …
pneumonia caused by the novel Middle East respiratory syndrome coronavirus (MERS-CoV). …
Transferrin-polycation conjugates as carriers for DNA uptake into cells.
We have developed a high-efficiency nucleic acid delivery system that uses receptor-mediated
endocytosis to carry DNA macromolecules into cells. We accomplished this by …
endocytosis to carry DNA macromolecules into cells. We accomplished this by …
Influenza virus hemagglutinin HA-2 N-terminal fusogenic peptides augment gene transfer by transferrin-polylysine-DNA complexes: toward a synthetic virus-like gene …
…, C Plank, K Zatloukal, M Cotten… - Proceedings of the …, 1992 - National Acad Sciences
… Pharmacia; gradient elution with 0-100%o buffer B in bufferA; buffer B = buffer A plus 3 M
NaCl; the peptide was eluted at 1 M NaCl) and subsequently by reverse-phase HPLC (Bio-Rad …
NaCl; the peptide was eluted at 1 M NaCl) and subsequently by reverse-phase HPLC (Bio-Rad …
Transferrin-polycation-DNA complexes: the effect of polycations on the structure of the complex and DNA delivery to cells.
… buffer B (buffer A plus 3 M sodium chloride)] to add sodium … concentration of 0.6 M in the
case of Tf-Lys200 or 1 M in the case … tions of -1.4 M in the case ofTf-Lys200and =2 M in the case …
case of Tf-Lys200 or 1 M in the case … tions of -1.4 M in the case ofTf-Lys200and =2 M in the case …
Cell cycle dependence of gene transfer by lipoplex, polyplex and recombinant adenovirus
S Brunner, T Sauer, S Carotta, M Cotten, M Saltik… - Gene therapy, 2000 - nature.com
The aim of this study was to investigate the influence of cell cycle on transfection efficiency.
Counterflow centrifugal elutriation was used which avoids possible side-effects from …
Counterflow centrifugal elutriation was used which avoids possible side-effects from …
Coupling of adenovirus to transferrin-polylysine/DNA complexes greatly enhances receptor-mediated gene delivery and expression of transfected genes.
We are developing efficient methods for gene transfer into tissue culture cells. We have
previously shown that coupling of a chimeric adenovirus with polylysine allowed the construction …
previously shown that coupling of a chimeric adenovirus with polylysine allowed the construction …
Adenovirus enhancement of transferrin-polylysine-mediated gene delivery.
Gene transfer may be accomplished by the receptor-mediated endocytosis pathway using
transferrin-polylysine conjugates. For some target cells, however, gene transfer by this vector …
transferrin-polylysine conjugates. For some target cells, however, gene transfer by this vector …
Transferrin-polycation-mediated introduction of DNA into human leukemic cells: stimulation by agents that affect the survival of transfected DNA or modulate transferrin …
M Cotten, F Längle-Rouault… - Proceedings of the …, 1990 - National Acad Sciences
… Cells were exposed to either 50 ,M desferrioxamine or 130 ,M cobalt chloride or both …
Both 130 AtM cobalt chloride and 50 ,M desferrioxamine yielded similar enhancements of …
Both 130 AtM cobalt chloride and 50 ,M desferrioxamine yielded similar enhancements of …