User profiles for M. Cotten

Matthew Cotten

Research Professor, Complex Adaptive Systems Initiative, Arizona State University
Verified email at asu.edu
Cited by 25625

Delivery of drugs, proteins and genes into cells using transferrin as a ligand for receptor-mediated endocytosis

E Wagner, D Curiel, M Cotten - Advanced Drug Delivery Reviews, 1994 - Elsevier
Transferrin, an iron-transporting serum glycoprotein, is efficiently taken up into cells by the
process of receptor-mediated endocytosis. Transferrin receptors are found on the surface of …

HIV-2: the forgotten AIDS virus

TI de Silva, M Cotten, SL Rowland-Jones - Trends in microbiology, 2008 - cell.com
… Matthew Cotten Matthew Cotten … HIV-2 isolates are less fit than HIV-1 group M viruses
when compared by competition between viral strains in tissue culture [ …

[HTML][HTML] Hospital outbreak of Middle East respiratory syndrome coronavirus

…, R Alhakeem, JA Al-Tawfiq, M Cotten… - … England Journal of …, 2013 - Mass Medical Soc
Background In September 2012, the World Health Organization reported the first cases of
pneumonia caused by the novel Middle East respiratory syndrome coronavirus (MERS-CoV). …

Transferrin-polycation conjugates as carriers for DNA uptake into cells.

E Wagner, M Zenke, M Cotten… - Proceedings of the …, 1990 - National Acad Sciences
We have developed a high-efficiency nucleic acid delivery system that uses receptor-mediated
endocytosis to carry DNA macromolecules into cells. We accomplished this by …

Influenza virus hemagglutinin HA-2 N-terminal fusogenic peptides augment gene transfer by transferrin-polylysine-DNA complexes: toward a synthetic virus-like gene …

…, C Plank, K Zatloukal, M Cotten… - Proceedings of the …, 1992 - National Acad Sciences
… Pharmacia; gradient elution with 0-100%o buffer B in bufferA; buffer B = buffer A plus 3 M
NaCl; the peptide was eluted at 1 M NaCl) and subsequently by reverse-phase HPLC (Bio-Rad …

Transferrin-polycation-DNA complexes: the effect of polycations on the structure of the complex and DNA delivery to cells.

E Wagner, M Cotten, R Foisner… - Proceedings of the …, 1991 - National Acad Sciences
… buffer B (buffer A plus 3 M sodium chloride)] to add sodium … concentration of 0.6 M in the
case of Tf-Lys200 or 1 M in the case … tions of -1.4 M in the case ofTf-Lys200and =2 M in the case …

Cell cycle dependence of gene transfer by lipoplex, polyplex and recombinant adenovirus

S Brunner, T Sauer, S Carotta, M Cotten, M Saltik… - Gene therapy, 2000 - nature.com
The aim of this study was to investigate the influence of cell cycle on transfection efficiency.
Counterflow centrifugal elutriation was used which avoids possible side-effects from …

Coupling of adenovirus to transferrin-polylysine/DNA complexes greatly enhances receptor-mediated gene delivery and expression of transfected genes.

E Wagner, K Zatloukal, M Cotten… - Proceedings of the …, 1992 - National Acad Sciences
We are developing efficient methods for gene transfer into tissue culture cells. We have
previously shown that coupling of a chimeric adenovirus with polylysine allowed the construction …

Adenovirus enhancement of transferrin-polylysine-mediated gene delivery.

…, S Agarwal, E Wagner, M Cotten - Proceedings of the …, 1991 - National Acad Sciences
Gene transfer may be accomplished by the receptor-mediated endocytosis pathway using
transferrin-polylysine conjugates. For some target cells, however, gene transfer by this vector …

Transferrin-polycation-mediated introduction of DNA into human leukemic cells: stimulation by agents that affect the survival of transfected DNA or modulate transferrin …

M Cotten, F Längle-Rouault… - Proceedings of the …, 1990 - National Acad Sciences
… Cells were exposed to either 50 ,M desferrioxamine or 130 ,M cobalt chloride or both …
Both 130 AtM cobalt chloride and 50 ,M desferrioxamine yielded similar enhancements of …