User profiles for M. Doumith

Michel Doumith

Scientist - Bioinformatician
Verified email at ukhsa.gov.uk
Cited by 15536

[HTML][HTML] The role of whole genome sequencing in antimicrobial susceptibility testing of bacteria: report from the EUCAST Subcommittee

…, FM Aarestrup, R Canton, M Doumith… - Clinical microbiology …, 2017 - Elsevier
Whole genome sequencing (WGS) offers the potential to predict antimicrobial susceptibility
from a single assay. The European Committee on Antimicrobial Susceptibility Testing …

[HTML][HTML] Emergence of a new antibiotic resistance mechanism in India, Pakistan, and the UK: a molecular, biological, and epidemiological study

…, R Balakrishnan, U Chaudhary, M Doumith… - The Lancet infectious …, 2010 - thelancet.com
Background Gram-negative Enterobacteriaceae with resistance to carbapenem conferred
by New Delhi metallo-β-lactamase 1 (NDM-1) are potentially a major global health problem. …

Differentiation of the Major Listeria monocytogenes Serovars by Multiplex PCR

M Doumith, C Buchrieser, P Glaser… - Journal of clinical …, 2004 - Am Soc Microbiol
A new multiplex PCR assay was developed to separate the four major Listeria monocytogenes
serovars isolated from food and patients (1/2a, 1/2b, 1/2c, and 4b) into distinct groups. …

Pathogenomics of Listeria spp.

…, K Neuhaus, TM Fuchs, S Scherer, M Doumith… - International Journal of …, 2007 - Elsevier
This review provides an overview of recent progress in the exploration of genomic, transcriptomic,
and proteomic data in Listeria spp. to understand genome evolution and diversity, as …

Molecular mechanisms disrupting porin expression in ertapenem-resistant Klebsiella and Enterobacter spp. clinical isolates from the UK

M Doumith, MJ Ellington, DM Livermore… - Journal of …, 2009 - academic.oup.com
Objectives The aim of this study was to investigate relatedness and molecular mechanism(s)
of ertapenem resistance in clinical isolates of Klebsiella spp. (n = 28) and Enterobacter spp. …

Phosphoethanolamine modification of lipid A in colistin-resistant variants of Acinetobacter baumannii mediated by the pmrAB two-component regulatory system

…, JA Bengoechea, M Doumith, M Hornsey… - Antimicrobial agents …, 2011 - Am Soc Microbiol
Colistin resistance is rare in Acinetobacter baumannii , and little is known about its mechanism.
We investigated the role of PmrCAB in this trait, using (i) resistant and susceptible clinical …

What remains against carbapenem-resistant Enterobacteriaceae? Evaluation of chloramphenicol, ciprofloxacin, colistin, fosfomycin, minocycline, nitrofurantoin …

…, M Warner, S Mushtaq, M Doumith… - International journal of …, 2011 - Elsevier
Carbapenem-resistant Enterobacteriaceae present an increasing and diverse problem,
including strains of multiple species with metallo-β-lactamases (IMP, NDM or VIM) and non-…

Identification of bacterial pathogens and antimicrobial resistance directly from clinical urines by nanopore-based metagenomic sequencing

…, LC Crossman, M Doumith… - Journal of …, 2016 - academic.oup.com
Objectives The introduction of metagenomic sequencing to diagnostic microbiology has
been hampered by slowness, cost and complexity. We explored whether MinION nanopore …

[HTML][HTML] Methicillin-resistant Staphylococcus aureus emerged long before the introduction of methicillin into clinical practice

CP Harkins, B Pichon, M Doumith, J Parkhill, H Westh… - Genome biology, 2017 - Springer
Background The spread of drug-resistant bacterial pathogens poses a major threat to global
health. It is widely recognised that the widespread use of antibiotics has generated selective …

New Aspects Regarding Evolution and Virulence of Listeria monocytogenes Revealed by Comparative Genomics and DNA Arrays

M Doumith, C Cazalet, N Simoes, L Frangeul… - Infection and …, 2004 - Am Soc Microbiol
… array, combined with the knowledge of the marker genes identified in this study, should
prove to be a powerful tool for identifying these strains (M. Doumith, C. Buchrieser, P. Glaser, C. …