Insulin-like growth factor binding protein-3 (IGFBP-3) is a p53 tumor suppressor-regulated
protein and a major carrier for IGFs in circulation. Among six high-affinity IGFBPs, which are …

Sjögren's syndrome is a common autoimmune disease (affecting ∼0.7% of European
Americans) that typically presents as keratoconjunctivitis sicca and xerostomia. Here we report …

Introduction: Epigenetics is the study of reversible modifications to chromatin and their
extensive and profound effects on gene regulation. To date, the role of epigenetics in …

Systemic lupus erythematosus is an autoimmune disease characterized by multi-system
involvement and autoantibody production. Abnormal T cell DNA methylation and type-I …

Systemic lupus erythematosus (SLE) has a strong but incompletely understood genetic
architecture. We conducted an association study with replication in 4,478 SLE cases and 12,656 …

… To identify differentially methylated CG sites between lupus patients and controls, we used
the associative analysis as described by Dozmorov et al.Citation23 CG sites with methylation …

The need for research investigating DNA methylation (DNAm) in clinical studies has increased,
leading to the evolution of new analytic methods to improve accuracy and reproducibility …

Identification of commensal dysbiosis as a host-intrinsic factor mediating evolution of metastatic
breast cancer allows for development of interventions or diagnostic tools for patients at …

This study shows how MYCN increases intracellular iron levels and subsequent GSH pathway
activity and demonstrates the antitumor activity of FDA-approved SAS and auranofin in …

Fibrosis is a common disease process in which profibrotic cells disturb organ function by
secreting disorganized extracellular matrix (ECM). Adipose tissue fibrosis occurs during obesity …