CRISPR screens are a powerful source of biological discovery, enabling the unbiased
interrogation of gene function in a wide range of applications and species. In pooled CRISPR …

RAF proteins are components of a conserved signaling pathway that regulates cellular
responses to extracellular signals. Despite over 20 years of research into the regulation and …

Object The current treatment of craniopharyngiomas is evolving into one of a multimodal
approach in which the aim is disease control and improved preservation of quality of life (QOL). …

Clinical responses to anticancer therapies are often restricted to a subset of patients. In some
cases, mutated cancer genes are potent biomarkers for responses to targeted agents. Here…

Cancers arise owing to the accumulation of mutations in critical genes that alter normal
programmes of cell proliferation, differentiation and death. As the first stage of a systematic …

Over 30 mutations of the B-RAF gene associated with human cancers have been identified,
the majority of which are located within the kinase domain. Here we show that of 22 B-RAF …

Alterations in cancer genomes strongly influence clinical responses to treatment and in many
instances are potent biomarkers for response to drugs. The Genomics of Drug Sensitivity in …

In Rspondin-based 3D cultures, Lgr5 stem cells from multiple organs form ever-expanding
epithelial organoids that retain their tissue identity. We report the establishment of tumor …

… [Tables S3B and S3C]) yielded four classes referred to as M, H, CD, and CA (Table S3D;
Supplemental Experimental Procedures). Class M is enriched for CG mutations, class H for …

Human liver cancer research currently lacks in vitro models that can faithfully recapitulate
the pathophysiology of the original tumor. We recently described a novel, near-physiological …