High‐throughput sequencing for biology and medicine
WW Soon, M Hariharan, MP Snyder - Molecular systems biology, 2013 - embopress.org
Advances in genome sequencing have progressed at a rapid pace, with increased throughput
accompanied by plunging costs. But these advances go far beyond faster and cheaper. …
accompanied by plunging costs. But these advances go far beyond faster and cheaper. …
[HTML][HTML] Host-virus interaction: a new role for microRNAs
MicroRNAs (miRNAs) are a new class of 18–23 nucleotide long non-coding RNAs that play
critical roles in a wide spectrum of biological processes. Recent reports also throw light into …
critical roles in a wide spectrum of biological processes. Recent reports also throw light into …
Access to the triplet excited states of organic chromophores
…, AT John, J Sunny, M Hariharan - Chemical Society …, 2020 - pubs.rsc.org
Over the last several decades, exploring the pathways to access the triplet excited states of
organic chromophores has been a stimulating area of research. Among the numerous …
organic chromophores has been a stimulating area of research. Among the numerous …
Annotation of functional variation in personal genomes using RegulomeDB
As the sequencing of healthy and disease genomes becomes more commonplace, detailed
annotation provides interpretation for individual variation responsible for normal and …
annotation provides interpretation for individual variation responsible for normal and …
[HTML][HTML] Architecture of the human regulatory network derived from ENCODE data
Transcription factors bind in a combinatorial fashion to specify the on-and-off states of genes;
the ensemble of these binding events forms a regulatory network, constituting the wiring …
the ensemble of these binding events forms a regulatory network, constituting the wiring …
[HTML][HTML] Personal omics profiling reveals dynamic molecular and medical phenotypes
Personalized medicine is expected to benefit from combining genomic information with regular
monitoring of physiological states by multiple high-throughput methods. Here, we present …
monitoring of physiological states by multiple high-throughput methods. Here, we present …
Variation in transcription factor binding among humans
M Kasowski, F Grubert, C Heffelfinger, M Hariharan… - science, 2010 - science.org
Differences in gene expression may play a major role in speciation and phenotypic diversity.
We examined genome-wide differences in transcription factor (TF) binding in several …
We examined genome-wide differences in transcription factor (TF) binding in several …
[HTML][HTML] Human body epigenome maps reveal noncanonical DNA methylation variation
Understanding the diversity of human tissues is fundamental to disease and requires linking
genetic information, which is identical in most of an individual’s cells, with epigenetic …
genetic information, which is identical in most of an individual’s cells, with epigenetic …
Attention embedded residual CNN for disease detection in tomato leaves
Automation in plant disease detection and diagnosis is one of the challenging research areas
that has gained significant attention in the agricultural sector. Traditional disease detection …
that has gained significant attention in the agricultural sector. Traditional disease detection …
[HTML][HTML] An encyclopedia of mouse DNA elements (Mouse ENCODE)
…, RE Thurman, SM Weissman, P Cayting, M Hariharan… - Genome biology, 2012 - Springer
To complement the human Encyclopedia of DNA Elements (ENCODE) project and to enable
a broad range of mouse genomics efforts, the Mouse ENCODE Consortium is applying the …
a broad range of mouse genomics efforts, the Mouse ENCODE Consortium is applying the …