[HTML][HTML] Multi-laboratory assessment of reproducibility, qualitative and quantitative performance of SWATH-mass spectrometry

…, AC Gingras, JM Held, M Hirayama-Kurogi… - Nature …, 2017 - nature.com
Quantitative proteomics employing mass spectrometry is an indispensable tool in life science
research. Targeted proteomics has emerged as a powerful approach for reproducible …

Large‐scale multiplex absolute protein quantification of drug‐metabolizing enzymes and transporters in human intestine, liver, and kidney microsomes by SWATH‐MS …

K Nakamura, M HirayamaKurogi, S Ito, T Kuno… - …, 2016 - Wiley Online Library
The purpose of the present study was to examine simultaneously the absolute protein
amounts of 152 membrane and membrane‐associated proteins, including 30 metabolizing …

Effect of intestinal flora on protein expression of drug-metabolizing enzymes and transporters in the liver and kidney of germ-free and antibiotics-treated mice

T Kuno, M Hirayama-Kurogi, S Ito… - Molecular …, 2016 - ACS Publications
Dysbiosis (alteration of intestinal flora) is associated with various host physiologies,
including diseases. The purpose of this study was to clarify the effect of dysbiosis on protein …

[HTML][HTML] Reduction in hepatic secondary bile acids caused by short-term antibiotic-induced dysbiosis decreases mouse serum glucose and triglyceride levels

T Kuno, M Hirayama-Kurogi, S Ito, S Ohtsuki - Scientific reports, 2018 - nature.com
Antibiotic-caused changes in intestinal flora (dysbiosis) can have various effects on the host.
Secondary bile acids produced by intestinal bacteria are ligands for specific nuclear …

Downregulation of GNA13-ERK network in prefrontal cortex of schizophrenia brain identified by combined focused and targeted quantitative proteomics

M Hirayama-Kurogi, Y Takizawa, Y Kunii… - Journal of …, 2017 - Elsevier
Schizophrenia is a disabling mental illness associated with dysfunction of the prefrontal
cortex, which affects cognition and emotion. The purpose of the present study was to identify …

Large-Scale Quantitative Comparison of Plasma Transmembrane Proteins between Two Human Blood–Brain Barrier Model Cell Lines, hCMEC/D3 and HBMEC/ciβ

…, T Uemura, M Hirayama-Kurogi… - Molecular …, 2019 - ACS Publications
Transmembrane (TM) proteins localized at the plasma membrane, such as transporters and
receptors, play important roles in regulating the selective permeability of the blood–brain …

[HTML][HTML] Identification of a Specific Translational Machinery via TCTP–EF1A2 Interaction Regulating NF1-associated Tumor Growth by Affinity Purification and Data …

…, H Okanishi, M Nagayama, M Hirayama-Kurogi… - Molecular & Cellular …, 2019 - ASBMB
Neurofibromatosis type 1 (NF1) is an autosomal dominant disease that predisposes individuals
to developing benign neurofibromas and malignant peripheral nerve sheath tumors (…

Involvement of an orphan transporter, SLC22A18, in cell growth and drug resistance of human breast cancer MCF7 cells

S Ito, Y Fujino, S Ogata, M Hirayama-Kurogi… - Journal of …, 2018 - Elsevier
… Shingo Ito, Seiryo Ogata, Yu Fujino, and Mio Hirayama-Kurogi conducted experiments and
performed data analysis. Shingo Ito and Sumio Ohtsuki wrote the article. All authors provided …

Knockdown of orphan transporter SLC22A18 impairs lipid metabolism and increases invasiveness of HepG2 cells

…, Y Fujino, S Ogata, M Hirayama-Kurogi… - Pharmaceutical …, 2019 - Springer
Purpose The aim of this work is to investigate the roles of solute carrier family 22 member
18 (SLC22A18) in lipid metabolism and in establishing the tumor phenotype of HepG2 cells. …

Proteomic analysis of small intestinal epithelial cells in antibiotic-treated mice: changes in drug transporters and metabolizing enzymes

T Kuno, M Hirayama-Kurogi, S Ito, S Ohtsuki - Drug Metabolism and …, 2019 - Elsevier
… Author links open overlay panel Takuya Kuno a b , Mio Hirayama-Kurogi a c , Shingo Ito a c
Hirayama-Kurogi, S. Ito, and S. Ohtsuki have contributed to the study design and manuscript …