… M. Hollstein and CCHarris are in the Laboratory of Human Carcinogenesis, National
Cancer Institute, National Institutes of Health, Bethesda, MD 20892. D. Sidransky and B. …

Somatic mutations in the TP53 gene are one of the most frequent alterations in human
cancers, and germline mutations are the underlying cause of Li-Fraumeni syndrome, which …

The crucial differences between normal cells and cancer cells stem from discrete changes
in specific genes controlling proliferation and tissue homeostasis. Over 100 such cancer-…

… The current IARC database was originally created by CC Harris, M. Hollstein, and their
collaborators at the National Cancer Institute, Bethesda, MD. It was then tranferred to IARC with …

A data base is described in which over 2,500 mutations in the p53 gene of human tumors
and tumor cell lines are compiled from a systematic search of reports published before 1 …

… Ashwood-Smith; neocarzinostatin was a gift of M. Hofnung; restriction enzymes were from …
EDTA) with 0.1 M NaCl, and the fragment was eluted with four washes of TE with 1 M NaCl (50 …

Publisher Summary The p53 protein is a tight, hydrophobic central globule containing the
DNA binding domain, flanked by accessible N- and C-terminal regions. This protein is …

TP53 gene mutations are one of the most frequent somatic events in cancer. The IARC TP53
Database ( http://p53.iarc.fr ) is a popular resource that compiles occurrence and phenotype …

In 1994 we described a list of ∼2500 point mutations in the p53 gene of human tumors and
cell lines which we had compiled from the published literature and made available …

Since 1989, about 570 different p53 mutations have been identified in more than 8000
human cancers. A database of these mutations was initiated by M. Hollstein and CC Harris in …