Context: This article presents the main results from a large‐scale analytical systematic review
on knowledge exchange interventions at the organizational and policymaking levels. The …

BACKGROUND & AIMS: Heritable factors contribute to the development of colorectal cancer.
Identifying the genetic loci associated with colorectal tumor formation could elucidate the …

DNA methylation, an important type of epigenetic modification in humans, participates in
crucial cellular processes, such as embryonic development, X-inactivation, genomic imprinting …

… As covariates, we recommend using the first m=2 principal components of the control summary
matrix, a choice with which we have obtained consistently good results; this is discussed …

Pancreatic cancer, a highly aggressive tumour type with uniformly poor prognosis,
exemplifies the classically held view of stepwise cancer development 1 . The current model of …

We used a candidate gene approach to identify a set of SNPs, located in a predicted regulatory
region on chromosome 1q44 downstream of NLRP3 (previously known as CIAS1 and …

… m 2 , 5-fluorouracil 2,400 mg/m 2 given over 46 hours, irinotecan 150 mg/m 2 , and oxaliplatin
85 mg/m … gemcitabine 1,000 mg/m 2 and nab-paclitaxel 125 mg/m 2 given intravenously at …

Most disease-associated genetic variants are noncoding, making it challenging to design
experiments to understand their functional consequences 1 , 2 . Identification of expression …

To further dissect the genetic architecture of colorectal cancer (CRC), we performed whole-genome
sequencing of 1,439 cases and 720 controls, imputed discovered sequence variants …

Genetic studies of human disease have traditionally focused on the detection of disease-causing
mutations in afflicted individuals. Here we describe a complementary approach that …