We consider some of the problems involved in current discussions on stem cells in adult
mammalian tissues. The present concepts involve a number of pitfalls, weaknesses and logical, …

Apoptosis‐inducing factor (AIF) is encoded by one single gene located on the X chromosome.
AIF is ubiquitously expressed, both in normal tissues and in a variety of cancer cell lines. …

Apoptosis research has recently experienced a change from a paradigm in which the nucleus
determined the apoptotic process to a paradigm in which caspases and, more recently, …

Mitochondria play a key part in the regulation of apoptosis (cell death) 1 , 2 . Their
intermembrane space contains several proteins that are liberated through the outer membrane in …

Background The role of intensive insulin therapy in patients with severe sepsis is uncertain.
Fluid resuscitation improves survival among patients with septic shock, but evidence is …

Trait-associated genetic variants affect complex phenotypes primarily via regulatory mechanisms
on the transcriptome. To investigate the genetics of gene expression, we performed cis…

… ; M Mendila organised the study, and discussed the report; M Rashford organised and
designed the study; E Kuhnt did statistical analyses and wrote the report; and M Loeffler designed …

Cerebral gliomas of World Health Organization (WHO) grade II and III represent a major
challenge in terms of histological classification and clinical management. Here, we asked …

Diffuse large B cell lymphoma (DLBCL), the most common lymphoid malignancy in adults,
is a clinically and genetically heterogeneous disease that is further classified into …

Background Cyclophosphamide, doxorubicin, vincristine, and prednisolone (CHOP) is used
to treat patients with non-Hodgkin lymphoma. Interval decrease from 3 weeks of treatment (…