Granular materials are of substantial importance in many industrial and natural processes,
yet their complex behaviours, ranging from mechanical properties of static packing to their …

Understanding the mechanisms that control chromosome folding in the nucleus of
eukaryotes and their contribution to gene regulation is a key open issue in molecular biology. …

The organization of the genome in the nucleus and the interactions of genes with their
regulatory elements are key features of transcriptional control and their disruption can cause …

… We first demonstrate how c m affects the equilibrium compaction state of the polymer (Fig.
S2). The extent of polymer folding is captured by measuring the squared radius of gyration, , …

Mammalian chromosomes fold into arrays of megabase‐sized topologically associating
domains ( TAD s), which are arranged into compartments spanning multiple megabases of …

The CCCTC-binding factor (CTCF) works together with the cohesin complex to drive the
formation of chromatin loops and topologically associating domains, but its role in gene …

Due to recent advances in experimental and theoretical approaches, the dynamic three-dimensional
organization (3D) of the nucleus has become a very active area of research in life …

The probability density function (PDF) of a global measure in a large class of highly correlated
systems has been suggested to be of the same functional form. Here, we identify the …

The three-dimensional (3D) structure of chromatin is intrinsically associated with gene
regulation and cell function 1 , 2 – 3 . Methods based on chromatin conformation capture have …

Chromosomes have a complex architecture in the cell nucleus, which serves vital functional
purposes, yet its structure and folding mechanisms remain still incompletely understood. …