Advances in genotyping technology have, over the past decade, enabled the focused search
for common genetic variation associated with human diseases and traits. With the recently …

Background VKORC1 and CYP2C9 are important contributors to warfarin dose variability,
but explain less variability for individuals of African descent than for those of European or …

Europe has played a major role in dog evolution, harbouring the oldest uncontested Palaeolithic
remains and having been the centre of modern dog breed creation. Here we sequence …

Cardiometabolic diseases are the leading cause of death worldwide. Despite a known genetic
component, our understanding of these diseases remains incomplete. Here, we analyzed …

Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic
variation influences the development of illness requiring critical care 1 or hospitalization 2 , 3 – …

Background: Familial hypercholesterolemia (FH) is the most common cardiovascular genetic
disorder and, if left untreated, is associated with increased risk of premature atherosclerotic …

Importance Cerebral palsy is a common neurodevelopmental disorder affecting movement
and posture that often co-occurs with other neurodevelopmental disorders. Individual cases …

Rare genetic disorders (RGDs) often exhibit significant clinical variability among affected
individuals, a disease characteristic termed variable expressivity. Recently, the aggregate effect …

Variants in ABCB1 and CYP2C19 have been identified as predictors of cardiac events
during clopidogrel therapy initiated after myocardial infarction (MI) or percutaneous coronary …

Coordination of fetal maturation with birth timing is essential for mammalian reproduction. In
humans, preterm birth is a disorder of profound global health significance. The signals …