PIWI-interacting RNAs (piRNAs) are a class of small non-coding RNAs that associate with
proteins of the PIWI clade of the Argonaute family. First identified in animal germ line cells, …

PIWI proteins and Piwi-interacting RNAs (piRNAs) have established and conserved roles in
repressing transposable elements (TEs) in the germline of animals. However, in several …

mRNA regulation is essential in germ cells and early embryos. In particular, late oogenesis
and early embryogenesis occur in the absence of transcription and rely on maternal mRNAs …

… We thank M. Benkirane for the gift of 2′-O-methyl anti-miR129. This work was supported
by the Centre National de la Recherche Scientifique UPR1142, the Agence Nationale de la …

… (L,M) Mitosis defects in embryos from twin mutant females visualized by DAPI staining. …
-F89-4 female (M). Bottom panels show high magnifications of images in L,M. Anterior is oriented …

… Interestingly, this functional redundancy does not occur in the female germ line, as decreasing
the level of CCR4 leads to female sterility (S Zaessinger and M Simonelig, unpublished …

… (Roche) was equilibrated in 0.1 M Tris-HCl (pH 8) and incubated for 3 h at room temperature
on a rotating wheel with 1.9 mL CISS 2G5 culture supernatant adjusted to 0.1 M Tris (pH 8). …

… The molecular weight marker (m), a fraction of the column void volume, and a reference …
and remains anchored through stage 10 (Figure 4M) and the remainder of oogenesis. We found …

… Orr-Weaver for gifts of antibodies; the Bloomington Stock Center for Drosophila stocks; M. …
destroyed in temporally distinct events that define separable phases of the G2-M transition. …

The Piwi-interacting RNA (piRNA) pathway plays an essential role in the repression of
transposons in the germline. Other functions of piRNAs such as post-transcriptional regulation of …