… Rosenthal, and M. von Zastrow, submitted for publication). Not only have these latter
compounds demonstrated varying intrinsic activities among the D 2 receptor-mediated effectors …

Cell signalling and endocytic membrane trafficking have traditionally been viewed as distinct
processes. Although our present understanding is incomplete and there are still great …

Morphine and related µ-opioid receptor (MOR) agonists remain among the most effective
drugs known for acute relief of severe pain. A major problem in treating painful conditions is …

A newly described coronavirus named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2),
which is the causative agent of coronavirus disease 2019 (COVID-19), has …

Activity-dependent modulation of synaptic efficacy in the brain contributes to neural circuit
development and experience-dependent plasticity. Although glia are affected by activity and …

The heterogeneity of neural gene expression and the spatially limited expression of many
low-abundance messenger RNAs in the brain has made cloning and analysis of such …

INTRODUCTION Neuromodulators, such as dopamine, norepinephrine, or serotonin, exert
powerful control over neural circuit dynamics that give rise to diverse neural function and …

Binding of hormones, growth factors and other cell modulators to cell-surface receptors
triggers a complex array of signal-transduction events. The activation of many receptors also …

… Lissin, DV, Carroll, RC, Nicoll, RA, Malenka, RC & von Zastrow, M. Rapid, activation-induced
redistribution of ionotropic glutamate receptors in cultured hippocampal neurons. J. …

… In this study, Mark von Zastrow and colleagues use conformation-specific single-chain
antibodies to directly probe the activation of the β2-adrenoceptor, which is a prototypical G-protein…