The European Collaborative on Personalized Early Detection and Prevention of Breast Cancer
(ENVISION) brings together several international research consortia working on different …

Abstract Knowledge about breast carcinogenesis has accumulated during the last decades
but has barely been translated into strategies for early detection or prevention of this …

BACKGROUND The reduction of ovarian cancer (OC) risk in women with a history of tubal
ligation (TL) has been reported repeatedly, mostly on small populations. We have aimed to …

… We use M.SssI-treated genomic DNA, frozen in aliquots, as a constant reference sample to
determine this ratio and to derive the standard curve 20 . Thus, we can define the percent of …

Background Ovarian cancer has a poor prognosis, with just 40% of patients surviving 5
years. We designed this trial to establish the effect of early detection by screening on ovarian …

Embryonic stem cells rely on Polycomb group proteins to reversibly repress genes required
for differentiation. We report that stem cell Polycomb group targets are up to 12-fold more …

… The methylation status of a specifc CpG site was calculated from the intensity of the
methylated (M) and unmethylated (U) alleles, as the ratio of fluorescent signals β = Max(M,0)/[Max(M,…

Breast cancer is one of the most common cancers in humans and will on average affect up
to one in eight women in their lifetime in the United States and Europe 1 . The Women’s …

The ubiquitin-proteasome system is a major regulatory pathway of protein degradation and
plays an important role in cellular division. Fbxw7 (or hCdc4), a member of the F-box family …

… and M Widschwendter designed the study, did data analysis and interpretation, and wrote
the manuscript. M Widschwendter initiated and supervised the entire study. HM Müller, M …