The potential of the diverse chemistries present in natural products (NP) for biotechnology
and medicine remains untapped because NP databases are not searchable with raw data …

Dereplication represents a key step for rapidly identifying known secondary metabolites in
complex biological matrices. In this context, liquid-chromatography coupled to high resolution …

Covering: 2013 to 2019 The exploration of the chemical diversity of extracts from various
biological sources has led to major drug discoveries. Over the past two decades, despite the …

It is a common problem in natural product therapeutic lead discovery programs that despite
good bioassay results in the initial extract, the active compound(s) may not be isolated during …

Molecular networking is becoming more and more popular into the metabolomic community
to organize tandem mass spectrometry (MS 2 ) data. Even though this approach allows the …

Lissoclinotoxin B, a new pentathiepin derivative, was isolated from the tunicate Lissoclinum
perforatum. Structure elucidation of this compound is described based on spectroscopic data…

Isohomohalichondrin B, a new structural type in the halichondrin group, has been isolated
from the deep-water New Zealandsponge Lissodendoryx sp. Like some other members of the …

ETHNOPHARMACOLOGICAL RELEVANCE: Baicalein, the active constituent derived from
Scutellaria baicalensis Georgi., has previously been shown to significantly restore the …

Variolin B (1), a new type of pyridopyrrolopyrimidine alkaloid with antitumour and antiviral
properties, has been isolated from the Antarctic sponge Kirkpatrickia varialosa, and its …

Molecular networking (MN) is becoming a standard bioinformatics tool in the metabolomic
community. Its paradigm is based on the observation that compounds with a high degree of …