Single-cell atlases often include samples that span locations, laboratories and conditions,
leading to complex, nested batch effects in data. Thus, joint analysis of atlas datasets requires …

Quantifying the impact of heritable epigenetic variation on complex traits is an emerging
challenge in population genetics. Here, we analyze a population of isogenic Arabidopsis lines …

Genetic mapping studies on crops suggest that agronomic traits can be controlled by gene–distal
intergenic loci. Despite the biological importance and the potential agronomic utility of …

Growing evidence shows that epigenetic mechanisms contribute to complex traits, with
implications across many fields of biology. In plant ecology, recent studies have attempted to …

Stochastic changes in cytosine methylation are a source of heritable epigenetic and
phenotypic diversity in plants. Using the model plant Arabidopsis thaliana, we derive robust …

Background Chromosome instability leads to aneuploidy, a state in which cells have abnormal
numbers of chromosomes, and is found in two out of three cancers. In a chromosomal …

The field of epigenomics has rapidly progressed from the study of individual reference
epigenomes to surveying epigenomic variation in populations. Recent studies in a number of …

Background Alzheimer’s disease (AD) is a neurodegenerative disease of the brain and the
most common form of dementia in the elderly. Aneuploidy, a state in which cells have an …

The rate of meiotic crossing over (CO) varies considerably along chromosomes, leading to
marked distortions between physical and genetic distances. The causes underlying this …

Histone 3 K4 trimethylation (depositing H3K4me3 marks) is typically associated with active
promoters yet paradoxically occurs at untranscribed domains. Research to delineate the …