Mechanisms regulating self-renewal and cell fate decisions in mammalian stem cells are
poorly understood. We determined global gene expression profiles for mouse and human …

The high-dimensional data created by high-throughput technologies require visualization
tools that reveal data structure and patterns in an intuitive form. We present PHATE, a …

In the developing cerebral cortex, neurons are born on a predictable schedule. Here we
show in mice that the essential timing mechanism is programmed within individual progenitor …

Knockout studies have shown that the polycomb gene Bmi-1 is important for postnatal, but
not embryonic, neural stem cell (NSC) self-renewal and have identified the cell-cycle …

… Four non-bound (NB) regions are shown as controls. Enrichment is shown as ChIP to
input … to and will be fulfilled by the Lead Contact, Natalia Ivanova (natalia.ivanova@yale.edu). …

As somatic cells are converted into induced pluripotent stem cells (iPSCs), their chromatin is
remodeled to a pluripotent configuration with unique euchromatin-to-heterochromatin ratios, …

Magnetic and Mössbauer spectroscopy (MS) measurements have been performed on a single
crystal of Co 2. 25 Fe 0. 75 O 2 BO 3 with ludwigite structure. Two magnetic transitions (TN…

In recent years, dimensionality reduction methods have become critical for visualization,
exploration, and interpretation of high-throughput, high-dimensional biological data, as they …

Nuclear hormone receptors are a family of transcription factors regulated by small molecules
derived from the endogenous metabolism or diet. There are forty-eight nuclear hormone …

With the advent of high-throughput technologies measuring high-dimensional biological
data, there is a pressing need for visualization tools that reveal data structure and emergent …