User profiles for N. J. Timpson
Nicholas John TimpsonUniversity of Bristol Verified email at bristol.ac.uk Cited by 98811 |
Strengthening the reporting of observational studies in epidemiology using Mendelian randomization: the STROBE-MR statement
Importance Mendelian randomization (MR) studies use genetic variation associated with
modifiable exposures to assess their possible causal relationship with outcomes and aim to …
modifiable exposures to assess their possible causal relationship with outcomes and aim to …
Genetic architecture: the shape of the genetic contribution to human traits and disease
Genetic architecture describes the characteristics of genetic variation that are responsible for
heritable phenotypic variability. It depends on the number of genetic variants affecting a trait…
heritable phenotypic variability. It depends on the number of genetic variants affecting a trait…
Association between genetic variants on chromosome 15q25 locus and objective measures of tobacco exposure
…, G Watt, TM Palmer, NJ Timpson… - Journal of the …, 2012 - academic.oup.com
Background Two single-nucleotide polymorphisms, rs1051730 and rs16969968, located
within the nicotinic acetylcholine receptor gene cluster on chromosome 15q25 locus, are …
within the nicotinic acetylcholine receptor gene cluster on chromosome 15q25 locus, are …
A Common Variant in the FTO Gene Is Associated with Body Mass Index and Predisposes to Childhood and Adult Obesity
Obesity is a serious international health problem that increases the risk of several common
diseases. The genetic factors predisposing to obesity are poorly understood. A genome-wide …
diseases. The genetic factors predisposing to obesity are poorly understood. A genome-wide …
Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes
…, G Thorleifsson, U Thorsteinsdottir, NJ Timpson… - Nature …, 2008 - nature.com
Genome-wide association (GWA) studies have identified multiple loci at which common variants
modestly but reproducibly influence risk of type 2 diabetes (T2D) 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , …
modestly but reproducibly influence risk of type 2 diabetes (T2D) 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , …
Common variants near MC4R are associated with fat mass, weight and risk of obesity
…, HE Syddall, SA Teichmann, NJ Timpson… - Nature …, 2008 - nature.com
To identify common variants influencing body mass index (BMI), we analyzed genome-wide
association data from 16,876 individuals of European descent. After previously reported …
association data from 16,876 individuals of European descent. After previously reported …
The MR-Base platform supports systematic causal inference across the human phenome
…, VY Tan, J Yarmolinsky, HA Shihab, NJ Timpson… - elife, 2018 - elifesciences.org
10.7554/eLife.34408.001 Results from genome-wide association studies (GWAS) can be
used to infer causal relationships between phenotypes, using a strategy known as 2-sample …
used to infer causal relationships between phenotypes, using a strategy known as 2-sample …
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index
…, F Rivadeneira, C Sandholt, LJ Scott, NJ Timpson… - Nature …, 2010 - nature.com
Obesity is globally prevalent and highly heritable, but its underlying genetic factors remain
largely elusive. To identify genetic loci for obesity susceptibility, we examined associations …
largely elusive. To identify genetic loci for obesity susceptibility, we examined associations …
Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes
The molecular mechanisms involved in the development of type 2 diabetes are poorly
understood. Starting from genome-wide genotype data for 1924 diabetic cases and 2938 …
understood. Starting from genome-wide genotype data for 1924 diabetic cases and 2938 …
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk
Levels of circulating glucose are tightly regulated. To identify new loci influencing glycemic
traits, we performed meta-analyses of 21 genome-wide association studies informative for …
traits, we performed meta-analyses of 21 genome-wide association studies informative for …