User profiles for N. J. Timpson

Nicholas John Timpson

University of Bristol
Verified email at bristol.ac.uk
Cited by 98811

Strengthening the reporting of observational studies in epidemiology using Mendelian randomization: the STROBE-MR statement

…, TJ VanderWeele, JPT Higgins, NJ Timpson… - Jama, 2021 - jamanetwork.com
Importance Mendelian randomization (MR) studies use genetic variation associated with
modifiable exposures to assess their possible causal relationship with outcomes and aim to …

Genetic architecture: the shape of the genetic contribution to human traits and disease

NJ Timpson, CMT Greenwood, N Soranzo… - Nature Reviews …, 2018 - nature.com
Genetic architecture describes the characteristics of genetic variation that are responsible for
heritable phenotypic variability. It depends on the number of genetic variants affecting a trait…

Association between genetic variants on chromosome 15q25 locus and objective measures of tobacco exposure

…, G Watt, TM Palmer, NJ Timpson… - Journal of the …, 2012 - academic.oup.com
Background Two single-nucleotide polymorphisms, rs1051730 and rs16969968, located
within the nicotinic acetylcholine receptor gene cluster on chromosome 15q25 locus, are …

A Common Variant in the FTO Gene Is Associated with Body Mass Index and Predisposes to Childhood and Adult Obesity

TM Frayling, NJ Timpson, MN Weedon, E Zeggini… - Science, 2007 - science.org
Obesity is a serious international health problem that increases the risk of several common
diseases. The genetic factors predisposing to obesity are poorly understood. A genome-wide …

Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes

…, G Thorleifsson, U Thorsteinsdottir, NJ Timpson… - Nature …, 2008 - nature.com
Genome-wide association (GWA) studies have identified multiple loci at which common variants
modestly but reproducibly influence risk of type 2 diabetes (T2D) 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , …

Common variants near MC4R are associated with fat mass, weight and risk of obesity

…, HE Syddall, SA Teichmann, NJ Timpson… - Nature …, 2008 - nature.com
To identify common variants influencing body mass index (BMI), we analyzed genome-wide
association data from 16,876 individuals of European descent. After previously reported …

The MR-Base platform supports systematic causal inference across the human phenome

…, VY Tan, J Yarmolinsky, HA Shihab, NJ Timpson… - elife, 2018 - elifesciences.org
10.7554/eLife.34408.001 Results from genome-wide association studies (GWAS) can be
used to infer causal relationships between phenotypes, using a strategy known as 2-sample …

Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index

…, F Rivadeneira, C Sandholt, LJ Scott, NJ Timpson… - Nature …, 2010 - nature.com
Obesity is globally prevalent and highly heritable, but its underlying genetic factors remain
largely elusive. To identify genetic loci for obesity susceptibility, we examined associations …

Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes

…, TM Frayling, KS Elliott, H Lango, NJ Timpson… - Science, 2007 - science.org
The molecular mechanisms involved in the development of type 2 diabetes are poorly
understood. Starting from genome-wide genotype data for 1924 diabetic cases and 2938 …

New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

…, C Cavalcanti-Proença, M Kumari, L Qi, NJ Timpson… - Nature …, 2010 - nature.com
Levels of circulating glucose are tightly regulated. To identify new loci influencing glycemic
traits, we performed meta-analyses of 21 genome-wide association studies informative for …