User profiles for N. L. Yozwiak
 | Nathan L YozwiakHead of Research, Gene and Cell Therapy Institute, Mass General Brigham Verified email at mgb.org Cited by 6437 |
Genomic surveillance elucidates Ebola virus origin and transmission during the 2014 outbreak
In its largest outbreak, Ebola virus disease is spreading through Guinea, Liberia, Sierra Leone,
and Nigeria. We sequenced 99 Ebola virus genomes from 78 patients in Sierra Leone to …
and Nigeria. We sequenced 99 Ebola virus genomes from 78 patients in Sierra Leone to …
Field-deployable viral diagnostics using CRISPR-Cas13
Mitigating global infectious disease requires diagnostic tools that are sensitive, specific, and
rapidly field deployable. In this study, we demonstrate that the Cas13-based SHERLOCK (…
rapidly field deployable. In this study, we demonstrate that the Cas13-based SHERLOCK (…
[HTML][HTML] Clinical illness and outcomes in patients with Ebola in Sierra Leone
Background Limited clinical and laboratory data are available on patients with Ebola virus
disease (EVD). The Kenema Government Hospital in Sierra Leone, which had an existing …
disease (EVD). The Kenema Government Hospital in Sierra Leone, which had an existing …
[PDF][PDF] Programmable inhibition and detection of RNA viruses using Cas13
The CRISPR effector Cas13 could be an effective antiviral for single-stranded RNA (ssRNA)
viruses because it programmably cleaves RNAs complementary to its CRISPR RNA (crRNA)…
viruses because it programmably cleaves RNAs complementary to its CRISPR RNA (crRNA)…
Virus genomes reveal factors that spread and sustained the Ebola epidemic
The 2013–2016 West African epidemic caused by the Ebola virus was of unprecedented
magnitude, duration and impact. Here we reconstruct the dispersal, proliferation and decline of …
magnitude, duration and impact. Here we reconstruct the dispersal, proliferation and decline of …
Zika virus evolution and spread in the Americas
Although the recent Zika virus (ZIKV) epidemic in the Americas and its link to birth defects
have attracted a great deal of attention 1 , 2 , much remains unknown about ZIKV disease …
have attracted a great deal of attention 1 , 2 , much remains unknown about ZIKV disease …
Genomic epidemiology reveals multiple introductions of Zika virus into the United States
…, KL West, SM Winnicki, S Wohl, NL Yozwiak… - Nature, 2017 - nature.com
Zika virus (ZIKV) is causing an unprecedented epidemic linked to severe congenital abnormalities
1 , 2 . In July 2016, mosquito-borne ZIKV transmission was reported in the continental …
1 , 2 . In July 2016, mosquito-borne ZIKV transmission was reported in the continental …
[HTML][HTML] Ebola virus epidemiology, transmission, and evolution during seven months in Sierra Leone
…, S Jalloh, D Nosamiefan, NL Yozwiak… - Cell, 2015 - cell.com
The 2013–2015 Ebola virus disease (EVD) epidemic is caused by the Makona variant of
Ebola virus (EBOV). Early in the epidemic, genome sequencing provided insights into virus …
Ebola virus (EBOV). Early in the epidemic, genome sequencing provided insights into virus …
[HTML][HTML] Data sharing: Make outbreak research open access
NL Yozwiak, SF Schaffner, PC Sabeti - Nature, 2015 - nature.com
… Yozwiak … Yozwiak, Stephen F. Schaffner and Pardis C. Sabeti. … Yozwiak and
Stephen F. Schaffner are senior staff scientists, and Pardis C. Sabeti is associate professor …
Stephen F. Schaffner are senior staff scientists, and Pardis C. Sabeti is associate professor …
[HTML][HTML] Virus identification in unknown tropical febrile illness cases using deep sequencing
Dengue virus is an emerging infectious agent that infects an estimated 50–100 million people
annually worldwide, yet current diagnostic practices cannot detect an etiologic pathogen …
annually worldwide, yet current diagnostic practices cannot detect an etiologic pathogen …