A vast number of different neuronal activity patterns could each induce a different set of
activity-regulated genes. Mapping this coupling between activity pattern and gene induction …

(R)-roscovitine (Ros) is a cyclin-dependent kinase inhibitor that also has been shown to have
direct agonist and antagonist actions on Ca v 2.1 (P/Q-type) and Ca v 2.2 (N-type) families …

The acute effect of the potent cyclin-dependent kinase (cdk) inhibitor (R)-roscovitine on Ca 2+
channels inspired the development of structural analogues as a potential treatment for …

Brief and sustained neuronal activity patterns can have opposite effects on synaptic strength
that both require activity-regulated gene (ARG) expression. However, whether distinct …

… Median survival of the whole cohort was 9.3 years (95% CI: 8-not reached-NR-). Through
penalized Cox regressions we identified negative predictors of survival and according to beta …

Experience-dependent neural activity initiates cascades of activity-regulated gene expression
that produce long-lasting changes in the adult brain. Different patterns of activity can …

… NR pts, indicating a statistically significant increase in lipids (cholesterol, triglycerides and
phospholipids) in NR … proinflammatory cytokines was demonstrated in NR pts plasma. Finally, …

Polycythemia vera (PV) and essential thrombocythemia (ET) are myeloproliferative neoplasms
(MPN) 1 that can progress to blast phase2 and to post-PV (PPV) myelofibrosis (MF) and …

In a randomized, phase 3 study, superior complete/near-complete response (CR/nCR) rates
and extended progression-free survival were demonstrated with bortezomib-thalidomide-…

We sought to identify new susceptibility loci for Alzheimer's disease through a staged
association study (GERAD+) and by testing suggestive loci reported by the Alzheimer's Disease …