Developmental signaling pathways control a vast array of biological processes during
embryogenesis and in adult life. The WNT pathway was discovered simultaneously in cancer and …

PTK7 (protein tyrosine kinase 7) is an evolutionarily conserved transmembrane receptor
with functions in various processes ranging from embryonic morphogenesis to epidermal …

Recent research on the WNT signaling pathway warrants a reassessment of the basic
mechanism that transmits signal from the membrane-bound receptor to the nucleus. This article …

… 2000), and Axin and TCF may play a role as cytoplasmic and nuclear anchors, respectively
(Tolwinski and Wieschglycoproteins that exert their effects on neighboring cells by binding to …

The mitogen-activated protein (MAP) kinase pathway, which includes extracellular signal–regulated
protein kinases 1 and 2 (ERK1, ERK2) and MAP kinase kinases 1 and 2 (MKK1, …

Wnt signalling is an evolutionarily conserved pathway that directs cell‐fate determination
and morphogenesis during metazoan development. Wnt ligands are secreted glycoproteins …

Drosophila melanogaster, known colloquially as the fruit fly, remains one of the most commonly
used model organisms for biomedical science. For more than one hundred years, the …

10.7554/eLife.26258.001 Morphogen gradients provide essential spatial information during
development. Not only the local concentration but also duration of morphogen exposure is …

The Wnt signaling pathway provides key information during development of vertebrates and
invertebrates, and mutations in this pathway lead to various forms of cancer. Wnt binding to …

There is growing interest in pharmacological interventions directly targeting the aging process.
Pharmacological interventions against aging should be efficacious when started in adults …