… Paraffin sections from formalin-fixed blocks of frontal (n 165) and occipital cortices (n 110),
as well as cerebellum (n 161) obtained from 187 brains, were processed by using the …

Background Follicular lymphoma is a clinically and genetically heterogeneous disease, but
the prognostic value of somatic mutations has not been systematically assessed. We aimed …

The genetics of angioimmunoblastic T-cell lymphoma (AITL) are very poorly understood.
We defined the mutational landscape of AITL across 219 genes in 85 cases from the United …

We investigated the therapeutic potential of JQ1, an inhibitor of the BET class of human
bromodomain proteins, in B-cell acute lymphoblastic leukemia (B-ALL). We show that JQ1 …

Chemotaxis is the movement of organisms toward or away from a chemical attractant or
toxin by a biased random walk process. Here we describe the first experimental example of …

More than 90% of drugs with preclinical activity fail in human trials, largely due to insufficient
efficacy. We hypothesized that adequately powered trials of patient-derived xenografts (PDX…

Loss of blood-brain barrier (BBB) integrity is believed to be an early and significant event in
lesion pathogenesis in the inflammatory demyelinating disease multiple sclerosis (MS), and …

… Accordingly, we identify three regions in PrP Sc : one N-terminal (residues 23–73) that is
invariably PK-sensitive, one C-terminal (residues 103–231) that is invariably PK-resistant, and …

This correspondence comments on the paper by Collinge et al. [VB 67, abst. 147] and report
the findings of immunoblot analysis of brain homogenate from 97 human cases of …

Objective: To investigate the possible association of persistent enterovirus (EV) infection
with the development of ALS. Background: Although ALS is a clinically well-defined motor …