Analysis of shared heritability in common disorders of the brain

…, GJ Falcone, P Gormley, R Malik, NA Patsopoulos… - Science, 2018 - science.org
INTRODUCTION Brain disorders may exhibit shared symptoms and substantial epidemiological
comorbidity, inciting debate about their etiologic overlap. However, detailed study of …

Uncertainty in heterogeneity estimates in meta-analyses

JPA Ioannidis, NA Patsopoulos, E Evangelou - Bmj, 2007 - bmj.com
… John Ioannidis, Nikolaos Patsopoulos, and Evangelos Evangelou argue that, although
meta-analyses often measure heterogeneity between studies, these estimates can have …

A pragmatic view on pragmatic trials

NA Patsopoulos - Dialogues in clinical neuroscience, 2011 - Taylor & Francis
… Les études pragmatiques fournissent des résultats qui peuvent être généralisés et appliqués
en pratique quotidienne, ce qui n'est pas le cas pour la plupart des études explicatives, et …

Genetic and epigenetic fine mapping of causal autoimmune disease variants

…, D Mayer, CJ Luckey, NA Patsopoulos… - Nature, 2015 - nature.com
Genome-wide association studies have identified loci underlying human diseases, but the
causal nucleotide changes and mechanisms remain largely unknown. Here we developed a …

Sensitivity of between-study heterogeneity in meta-analysis: proposed metrics and empirical evaluation

NA Patsopoulos, E Evangelou… - International journal of …, 2008 - academic.oup.com
… In this approach, for a meta-analysis of n studies, we perform n new meta-analyses, where
… The study that is responsible for the largest decrease in I 2 is dropped and a new set of n−1 …

Polarization of the effects of autoimmune and neurodegenerative risk alleles in leukocytes

…, S Imboywa, A Von Korff, Y Okada, NA Patsopoulos… - Science, 2014 - science.org
To extend our understanding of the genetic basis of human immune function and dysfunction,
we performed an expression quantitative trait locus (eQTL) study of purified CD4 + T cells …

Relative citation impact of various study designs in the health sciences

NA Patsopoulos, AA Analatos, JPA Ioannidis - Jama, 2005 - jamanetwork.com
ContextThe relative merits of various study designs and their placement in hierarchies of
evidence are often discussed. However, there is limited knowledge about the relative citation …

Reasons or excuses for avoiding meta-analysis in forest plots

JPA Ioannidis, NA Patsopoulos, HR Rothstein - Bmj, 2008 - bmj.com
… John Ioannidis, Nikolaos Patsopoulos, and Hannah Rothstein show that final synthesis is
possible and desirable in most cases … Ioannidis JP, Patsopoulos NA, Evangelou E …

[HTML][HTML] Fine-mapping the genetic association of the major histocompatibility complex in multiple sclerosis: HLA and non-HLA effects

NA Patsopoulos, LF Barcellos, RQ Hintzen… - PLoS …, 2013 - journals.plos.org
… The five included principal components are represented in the model as l and the last
block in the model represents the dummy variables included for the n studies (n-1 parameters …

Genome‐wide meta‐analysis identifies novel multiple sclerosis susceptibility loci

NA Patsopoulos… - Annals of …, 2011 - Wiley Online Library
… The probes that passed our quality check criteria (n = 20,517) were used for the subsequent
analyses. In an exploratory analysis, we performed an expression quantitative trait locus (…