Analysis of shared heritability in common disorders of the brain
…, GJ Falcone, P Gormley, R Malik, NA Patsopoulos… - Science, 2018 - science.org
INTRODUCTION Brain disorders may exhibit shared symptoms and substantial epidemiological
comorbidity, inciting debate about their etiologic overlap. However, detailed study of …
comorbidity, inciting debate about their etiologic overlap. However, detailed study of …
Uncertainty in heterogeneity estimates in meta-analyses
JPA Ioannidis, NA Patsopoulos, E Evangelou - Bmj, 2007 - bmj.com
… John Ioannidis, Nikolaos Patsopoulos, and Evangelos Evangelou argue that, although
meta-analyses often measure heterogeneity between studies, these estimates can have …
meta-analyses often measure heterogeneity between studies, these estimates can have …
A pragmatic view on pragmatic trials
NA Patsopoulos - Dialogues in clinical neuroscience, 2011 - Taylor & Francis
… Les études pragmatiques fournissent des résultats qui peuvent être généralisés et appliqués
en pratique quotidienne, ce qui n'est pas le cas pour la plupart des études explicatives, et …
en pratique quotidienne, ce qui n'est pas le cas pour la plupart des études explicatives, et …
Genetic and epigenetic fine mapping of causal autoimmune disease variants
…, D Mayer, CJ Luckey, NA Patsopoulos… - Nature, 2015 - nature.com
Genome-wide association studies have identified loci underlying human diseases, but the
causal nucleotide changes and mechanisms remain largely unknown. Here we developed a …
causal nucleotide changes and mechanisms remain largely unknown. Here we developed a …
Sensitivity of between-study heterogeneity in meta-analysis: proposed metrics and empirical evaluation
NA Patsopoulos, E Evangelou… - International journal of …, 2008 - academic.oup.com
… In this approach, for a meta-analysis of n studies, we perform n new meta-analyses, where
… The study that is responsible for the largest decrease in I 2 is dropped and a new set of n−1 …
… The study that is responsible for the largest decrease in I 2 is dropped and a new set of n−1 …
Polarization of the effects of autoimmune and neurodegenerative risk alleles in leukocytes
To extend our understanding of the genetic basis of human immune function and dysfunction,
we performed an expression quantitative trait locus (eQTL) study of purified CD4 + T cells …
we performed an expression quantitative trait locus (eQTL) study of purified CD4 + T cells …
Relative citation impact of various study designs in the health sciences
NA Patsopoulos, AA Analatos, JPA Ioannidis - Jama, 2005 - jamanetwork.com
ContextThe relative merits of various study designs and their placement in hierarchies of
evidence are often discussed. However, there is limited knowledge about the relative citation …
evidence are often discussed. However, there is limited knowledge about the relative citation …
Reasons or excuses for avoiding meta-analysis in forest plots
JPA Ioannidis, NA Patsopoulos, HR Rothstein - Bmj, 2008 - bmj.com
… John Ioannidis, Nikolaos Patsopoulos, and Hannah Rothstein show that final synthesis is
possible and desirable in most cases … Ioannidis JP, Patsopoulos NA, Evangelou E …
possible and desirable in most cases … Ioannidis JP, Patsopoulos NA, Evangelou E …
[HTML][HTML] Fine-mapping the genetic association of the major histocompatibility complex in multiple sclerosis: HLA and non-HLA effects
NA Patsopoulos, LF Barcellos, RQ Hintzen… - PLoS …, 2013 - journals.plos.org
… The five included principal components are represented in the model as l and the last
block in the model represents the dummy variables included for the n studies (n-1 parameters …
block in the model represents the dummy variables included for the n studies (n-1 parameters …
Genome‐wide meta‐analysis identifies novel multiple sclerosis susceptibility loci
NA Patsopoulos… - Annals of …, 2011 - Wiley Online Library
… The probes that passed our quality check criteria (n = 20,517) were used for the subsequent
analyses. In an exploratory analysis, we performed an expression quantitative trait locus (…
analyses. In an exploratory analysis, we performed an expression quantitative trait locus (…