To gain insight into how genomic information is translated into cellular and developmental
programs, the Drosophila model organism Encyclopedia of DNA Elements (modENCODE) …

Many approaches to identify therapeutically relevant neoantigens couple tumor sequencing
with bioinformatic algorithms and inferred rules of tumor epitope immunogenicity. However, …

Pancreatic cancer is the most lethal common solid malignancy. Systemic therapies are often
ineffective, and predictive biomarkers to guide treatment are urgently needed. We …

Fibrolamellar hepatocellular carcinoma (FL-HCC) is a rare liver tumor affecting adolescents
and young adults with no history of primary liver disease or cirrhosis. We identified a …

… either beginning at weaning at day 28 of life (LDP-w, n = 5 male, 6 female), or from birth (LDP-b,
n = 5 male, 4 female). Control mice had no penicillin exposure (n = 6 male, 5 female). …

Canonical animal microRNAs (miRNAs) are generated by sequential cleavage of precursor
substrates by the Drosha and Dicer RNase III enzymes. Several variant pathways exploit …

… However, we observed no overall enrichment for TEs in the 30UTRs of piRNA-generating
mRNAs (data not shown). Indeed, many Drosophila and mammalian 30UTRs with highest …

… This resulted in defects in embryo patterning: a total of 35% (n = 1,894) of embryos from
nos(Δ3) females did not hatch and among them 86% (n = 28) showed head skeleton defects (Fig…

The function of histone modifications in initiating and regulating the chromosomal events of
the meiotic prophase remains poorly understood. In Saccharomyces cerevisiae, we …

… For further confirmation of these results, we cloned the region of DEK that is N-terminal to
the fusion breakpoint (DEK-N-term), or DEK fused to an equal length of AFF2 C-terminal to the …