Recent research on disparate psychiatric disorders has implicated rare variants in genes
involved in global gene regulation and chromatin modification, as well as many common …

The human CNS follows a pattern of development typical of all mammals, but certain
neurodevelopmental features are highly derived. Building the human CNS requires the precise …

The cerebral neocortex is segregated into six horizontal layers, each containing unique
populations of molecularly and functionally distinct excitatory projection (pyramidal) neurons and …

Multiple studies have confirmed the contribution of rare de novo copy number variations to
the risk for autism spectrum disorders 1 , 2 , 3 . But whereas de novo single nucleotide …

Brain development and function depend on the precise regulation of gene expression.
However, our understanding of the complexity and dynamics of the transcriptome of the human …

The anatomical and functional architecture of the human brain is mainly determined by prenatal
transcriptional processes. We describe an anatomically comprehensive atlas of the mid-…

Tourette's syndrome (TS) is a genetically influenced developmental neuropsychiatric disorder
characterized by chronic vocal and motor tics. We studied Slit and Trk-like 1 (SLITRK1) as …

Background MicroRNAs are a large new class of tiny regulatory RNAs found in nematodes,
plants, insects and mammals. MicroRNAs are thought to act as post-transcriptional …

Autism spectrum disorder (ASD) is a complex developmental syndrome of unknown etiology.
Recent studies employing exome- and genome-wide sequencing have identified nine high-…

The exuberant growth of neurites during development becomes markedly reduced as
cortical neurons mature. In vitro studies of neurons from mouse cerebral cortex revealed that …