ContextProstate cancer is the most common nonskin cancer and second most common cause
of cancer mortality in US men. Androgen deprivation therapy (ADT), specifically surgical or …

The androgen-signaling axis plays a pivotal role in the pathogenesis of prostate cancer.
Since the landmark discovery by Huggins and Hodges, gonadal depletion of androgens has …

Heat pipes (HPs) and thermosyphons (TSs) are widely recognized as being excellent
passive thermal transport devices that can have effective thermal conductivities orders of …

We report heterozygous mutations in the genes encoding either type I or type II transforming
growth factor β receptor in ten families with a newly described human phenotype that …

Introduction Monocytes circulate in the bloodstream for up to 3 to 5 days. Concomitantly,
immunological imprinting of either tolerance (immunosuppression) or trained immunity (innate …

Many common variants have been associated with hematological traits, but identification of
causal genes and pathways has proven challenging. We performed a genome-wide …

Premature termination codons induce rapid transcript degradation in eukaryotic cells through
nonsense-mediated mRNA decay (NMD) 1 , 2 . This pathway can modulate phenotypes …

Long-range interactions between regulatory elements and gene promoters play key roles in
transcriptional regulation. The vast majority of interactions are uncharted, constituting a …

Drosophila melanogaster has a rich repertoire of innate and learned behaviors. Its 100,000-neuron
brain is a large but tractable target for comprehensive neural circuit mapping. Only …

Characterizing the multifaceted contribution of genetic and epigenetic factors to disease
phenotypes is a major challenge in human genetics and medicine. We carried out high-…