The increase of publicly available bioactivity data in recent years has fueled and catalyzed
research in chemogenomics, data mining, and modeling approaches. As a direct result, over …

Transforming growth factor‐β (TGF‐β) superfamily members are multifunctional cell‐cell
signaling proteins that play pivotal roles in tissue homeostasis and development of multicellular …

During early development, cells receive positional information from neighboring cells to form
tissue patterns in initially uniform germ layers. Ligands of the transforming growth factor (…

… Receptors for members of the TGF-[3 superfamily, including BMPs, have been molecularly
cloned and characterized (for a recent review, see ten Dijke et al. 4o). Most of the members in …

… Peter ten Dijke … Peter ten Dijke … Ski can also recruit HDACs indirectly through proteins
like N-CoR and Sin3A [105,106]. In addition, Ski can also inhibit transcription by competing with …

Changes in glycosylation signatures of cells have been associated with pathological
processes in cancer as well as infectious and autoimmune diseases. The current protocols for …

Background and Aims In patients with acute liver failure (ALF) who suffer from massive
hepatocyte loss, liver progenitor cells (LPCs) take over key hepatocyte functions, which ultimately …

… C-terminal domain of Smad7 was also exported from the nucleus to the cytoplasm upon
TGF-β challenge, a Smad7 mutant with a small deletion at the C terminus or only the N-terminal …

Members of the transforming growth factor-β (TGF-β) family transmit signals from membrane
to nucleus via intracellular proteins known as Smads. A subclass of Smad proteins has …

… A blot with mRNAs from mouse tissues was hybridized with an N-terminal domain Smad7 …
results on TGF-β signalling, suggesting that N-terminal tagging does not interfere with Smad7 …