Transposable elements (TEs) are a prolific source of tightly regulated, biochemically active
non-coding elements, such as transcription factor-binding sites and non-coding RNAs. Many …

The ciliate Tetrahymena thermophila is a model organism for molecular and cellular biology.
Like other ciliates, this species has separate germline and soma functions that are …

… We thank all members of the Elde and Feschotte labs for insightful discussions. We thank A.
… We thank all members of the Elde and Feschotte labs for insightful discussions. We thank A. …

In contrast to RNA viruses, double-stranded DNA viruses have low mutation rates yet must
still adapt rapidly in response to changing host defenses. To determine mechanisms of …

Distinguishing self from non-self is a fundamental biological challenge. Many pathogens
exploit the challenge of self discrimination by employing mimicry to subvert key cellular …

Interferon γ-inducible protein 16 (IFI16) and cGMP-AMP synthase (cGAS) have both been
proposed to detect herpesviral DNA directly in herpes simplex virus (HSV)-infected cells and …

Evolutionary conflicts involving mimicry are found throughout nature. Diverse pathogens
produce a range of 'mimics' that resemble host components in both form and function. Such …

Iron sequestration provides an innate defense, termed nutritional immunity, leading
pathogens to scavenge iron from hosts. Although the molecular basis of this battle for iron is …

Existing methods for identifying structural variants (SVs) from short read datasets are
inaccurate. This complicates disease-gene identification and efforts to understand the …

Host–pathogen interactions provide valuable systems for the study of evolutionary genetics
and natural selection. The sequestration of essential iron has emerged as a crucial innate …