Biological insights from 108 schizophrenia-associated genetic loci

…, SA McCarroll, A McQuillin, JL Moran, PB Mortensen… - Nature, 2014 - nature.com
Schizophrenia is a highly heritable disorder. Genetic risk is conferred by a large number of
alleles, including common alleles of small effect that might be detected by genome-wide …

Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder

…, DM Hougaard, T Werge, O Mors, PB Mortensen… - Nature …, 2019 - nature.com
Attention deficit/hyperactivity disorder (ADHD) is a highly heritable childhood behavioral
disorder affecting 5% of children and 2.5% of adults. Common genetic variants contribute …

Common variants conferring risk of schizophrenia

…, T Werge, OPH Pietiläinen, O Mors, PB Mortensen… - Nature, 2009 - nature.com
Schizophrenia is a complex disorder, caused by both genetic and environmental factors and
their interactions. Research on pathogenesis has traditionally focused on neurotransmitter …

[PDF][PDF] The Danish civil registration system

…, H Gøtzsche, JØ Møller, PB Mortensen - Dan Med …, 2006 - content.ugeskriftet.dk
… Pedersen CB, Mortensen PB. Family history, place and season of birth as risk factors for
schizophrenia in Denmark: a replication and reanalysis. Br J Psychiatry 2001;179:46-52. …

Identification of common genetic risk variants for autism spectrum disorder

…, DM Hougaard, T Werge, O Mors, PB Mortensen… - Nature …, 2019 - nature.com
Autism spectrum disorder (ASD) is a highly heritable and heterogeneous group of
neurodevelopmental phenotypes diagnosed in more than 1% of children. Common genetic variants …

Genome-wide association analysis identifies 13 new risk loci for schizophrenia

…, KS Kendler, K Lin, DW Morris, O Mors, PB Mortensen… - Nature …, 2013 - nature.com
Schizophrenia is an idiopathic mental disorder with a heritable component and a substantial
public health impact. We conducted a multi-stage genome-wide association study (GWAS) …

[PDF][PDF] Large-scale exome sequencing study implicates both developmental and functional changes in the neurobiology of autism

…, D Moreira, EM Morrow, O Mors, PB Mortensen… - Cell, 2020 - cell.com
We present the largest exome sequencing study of autism spectrum disorder (ASD) to date (n
= 35,584 total samples, 11,986 with ASD). Using an enhanced analytical framework to …

Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection

…, OA Andreassen, M Bækvad-Hansen, PB Mortensen… - Nature …, 2018 - nature.com
Schizophrenia is a debilitating psychiatric condition often associated with poor quality of life
and decreased life expectancy. Lack of progress in improving treatment outcomes has been …

The Danish psychiatric central research register

…, GP Perto, PB Mortensen - Scandinavian journal of …, 2011 - journals.sagepub.com
Introduction: The Psychiatric Central Research Register (PCRR) has continued since 1970
with electronic registration of patients treated at psychiatric departments in Denmark. Content…

Rare coding variants in ten genes confer substantial risk for schizophrenia

…, L Milani, CP Morley, DW Morris, PB Mortensen… - Nature, 2022 - nature.com
Rare coding variation has historically provided the most direct connections between gene
function and disease pathogenesis. By meta-analysing the whole exomes of 24,248 …