De novo assembly of RNA-seq data enables researchers to study transcriptomes without
the need for a genome sequence; this approach can be usefully applied, for instance, in …

Methods for assembly, taxonomic profiling and binning are key to interpreting metagenome
data, but a lack of consensus about benchmarking complicates performance assessment. …

… The system pressure was maintained at 1 atm by using a Langevin-piston barostat (25)
with a piston period of 2 ps and a damping time of 2 ps. Short-range nonbonded interactions …

We present a new transcriptome assembly of the Pacific whiteleg shrimp (Litopenaeus
vannamei), the species most farmed for human consumption. Its functional annotation, a …

… ) with a piston period of 2 ps and a damping time of 2 ps. Short-range nonbonded
interactions were cut off smoothly between 10 and 12 Å. The particle mesh Ewald algorithm ( …

Background The Cancer Genome Atlas Project (TCGA) is a National Cancer Institute effort
to profile at least 500 cases of 20 different tumor types using genomic platforms and to make …

Liposome remodeling processes (eg, vesiculation and tubulation) due to N-BAR domain
interactions with the lipid bilayer are explored with a multi-scale simulation approach. Results …

… Accordingly, therapeutic blockade of PD-1 or PD-L1 in patients with cancer has heralded
a … how the PD-1/PD-L1 pathway affects the immunopathogenesis of human blood vessel …

… In addition, we studied regional patterns of the association of age, sex, and time period with
… blood pressure and smoking prevalence with SAH incidence. To describe patterns of blood …

… We propose that peripheral blood monitoring can be used to study responses to PD-1–targeted
therapies; however, it is imperative to perform a careful analysis with adequate markers …