User profiles for P. G. Holt

Patrick Holt

Professor, Telethon Kids Institute, University of Western Australia
Verified email at telethonkids.org.au
Cited by 55801

After asthma: redefining airways diseases

…, JV Fahy, U Frey, P Gibson, LG Heaney, PG Holt… - The Lancet, 2018 - thelancet.com
Asthma is responsible for considerable global morbidity and health-care costs. Substantial
progress was made against key outcomes such as hospital admissions with asthma and …

[HTML][HTML] The role of allergy in the development of asthma

PG Holt, C Macaubas, PA Stumbles, PD Sly - Nature, 1999 - nature.com
Recent studies have shown that initial sensitization to airborne environmental allergens
occurs typically in early childhood, but subsequent progression to persistent atopic asthma, …

[HTML][HTML] Immune and inflammatory function in cigarette smokers.

PG Holt - Thorax, 1987 - ncbi.nlm.nih.gov
… This work (reviewed by Holt and Keast') defined a discrete pattern of change in animals
during the course of tobacco smoke exposure, with the following salient features:(1) systemically, …

Development of allergen-specific T-cell memory in atopic and normal children

…, T Smallacombe, BJ Holt, PD Sly, PG Holt - The Lancet, 1999 - thelancet.com
… SL Prescott, C Macaubas, PD Sly, and PG Holt shared responsibility for design, analysis, …
Laboratory work was done by SL Prescott, with assistance from T Smallacombe and BJ Holt

Transplacental priming of the human immune system to environmental allergens: universal skewing of initial T cell responses toward the Th2 cytokine profile

…, TB Smallacombe, R Loh, PD Sly, PG Holt - The Journal of …, 1998 - journals.aai.org
… was detected in cultures stimulated with either allergen, up to 10 pg/ml culture fluid (Fig. 6). …
involving secretion of this cytokine at levels up to 3000 pg/ml culture fluid. This high level of …

Downregulation of the antigen presenting cell function (s) of pulmonary dendritic cells in vivo by resident alveolar macrophages.

PG Holt, J Oliver, N Bilyk, C McMenamin… - The Journal of …, 1993 - rupress.org
… Kraal, and PG Holt. 1991. Regulation of immune response to inhaled antigen by alveolar
macrophages (AM): differential effects of in vivo AM elimination on the induction of tolerance …

A Polymorphism* in the 5′ flanking region of the CD14 gene is associated with circulating soluble CD14 levels and with total serum immunoglobulin E

…, M Halonen, RP Erickson, PG Holt… - American journal of …, 1999 - atsjournals.org
… (95% CI) were 63.6 pg/ml (49.2 to 82.2) for 67 CC subjects and 67.8 pg/ml (50.9 to 90.5) for
Holt PGPrimary allergic sensitization to environmental antigens: perinatal T-cell priming as a …

[HTML][HTML] The infant nasopharyngeal microbiome impacts severity of lower respiratory infection and risk of asthma development

…, SL Johnston, JE Gern, PD Sly, PG Holt, KE Holt… - Cell host & …, 2015 - cell.com
The nasopharynx (NP) is a reservoir for microbes associated with acute respiratory
infections (ARIs). Lung inflammation resulting from ARIs during infancy is linked to asthma …

Association between breast feeding and asthma in 6 year old children: findings of a prospective birth cohort study

WH Oddy, PG Holt, PD Sly, AW Read, LI Landau… - Bmj, 1999 - bmj.com
Objectives: To investigate the association between the duration of exclusive breast feeding
and the development of asthma related outcomes in children at age 6 years. Design: …

Early-life respiratory viral infections, atopic sensitization, and risk of subsequent development of persistent asthma

…, NH de Klerk, T Kebadze, V Vohma, PG Holt… - Journal of Allergy and …, 2007 - Elsevier
BACKGROUND: Severe lower respiratory infections (LRIs) and atopic sensitization have
been identified as independent risk factors for asthma. OBJECTIVE: The nature of potential …