User profiles for P. G. Holt
Patrick HoltProfessor, Telethon Kids Institute, University of Western Australia Verified email at telethonkids.org.au Cited by 55801 |
After asthma: redefining airways diseases
Asthma is responsible for considerable global morbidity and health-care costs. Substantial
progress was made against key outcomes such as hospital admissions with asthma and …
progress was made against key outcomes such as hospital admissions with asthma and …
[HTML][HTML] The role of allergy in the development of asthma
Recent studies have shown that initial sensitization to airborne environmental allergens
occurs typically in early childhood, but subsequent progression to persistent atopic asthma, …
occurs typically in early childhood, but subsequent progression to persistent atopic asthma, …
[HTML][HTML] Immune and inflammatory function in cigarette smokers.
PG Holt - Thorax, 1987 - ncbi.nlm.nih.gov
… This work (reviewed by Holt and Keast') defined a discrete pattern of change in animals
during the course of tobacco smoke exposure, with the following salient features:(1) systemically, …
during the course of tobacco smoke exposure, with the following salient features:(1) systemically, …
Development of allergen-specific T-cell memory in atopic and normal children
… SL Prescott, C Macaubas, PD Sly, and PG Holt shared responsibility for design, analysis, …
Laboratory work was done by SL Prescott, with assistance from T Smallacombe and BJ Holt…
Laboratory work was done by SL Prescott, with assistance from T Smallacombe and BJ Holt…
Transplacental priming of the human immune system to environmental allergens: universal skewing of initial T cell responses toward the Th2 cytokine profile
… was detected in cultures stimulated with either allergen, up to 10 pg/ml culture fluid (Fig. 6). …
involving secretion of this cytokine at levels up to 3000 pg/ml culture fluid. This high level of …
involving secretion of this cytokine at levels up to 3000 pg/ml culture fluid. This high level of …
Downregulation of the antigen presenting cell function (s) of pulmonary dendritic cells in vivo by resident alveolar macrophages.
PG Holt, J Oliver, N Bilyk, C McMenamin… - The Journal of …, 1993 - rupress.org
… Kraal, and PG Holt. 1991. Regulation of immune response to inhaled antigen by alveolar
macrophages (AM): differential effects of in vivo AM elimination on the induction of tolerance …
macrophages (AM): differential effects of in vivo AM elimination on the induction of tolerance …
A Polymorphism* in the 5′ flanking region of the CD14 gene is associated with circulating soluble CD14 levels and with total serum immunoglobulin E
…, M Halonen, RP Erickson, PG Holt… - American journal of …, 1999 - atsjournals.org
… (95% CI) were 63.6 pg/ml (49.2 to 82.2) for 67 CC subjects and 67.8 pg/ml (50.9 to 90.5) for
… Holt PGPrimary allergic sensitization to environmental antigens: perinatal T-cell priming as a …
… Holt PGPrimary allergic sensitization to environmental antigens: perinatal T-cell priming as a …
[HTML][HTML] The infant nasopharyngeal microbiome impacts severity of lower respiratory infection and risk of asthma development
The nasopharynx (NP) is a reservoir for microbes associated with acute respiratory
infections (ARIs). Lung inflammation resulting from ARIs during infancy is linked to asthma …
infections (ARIs). Lung inflammation resulting from ARIs during infancy is linked to asthma …
Association between breast feeding and asthma in 6 year old children: findings of a prospective birth cohort study
Objectives: To investigate the association between the duration of exclusive breast feeding
and the development of asthma related outcomes in children at age 6 years. Design: …
and the development of asthma related outcomes in children at age 6 years. Design: …
Early-life respiratory viral infections, atopic sensitization, and risk of subsequent development of persistent asthma
…, NH de Klerk, T Kebadze, V Vohma, PG Holt… - Journal of Allergy and …, 2007 - Elsevier
BACKGROUND: Severe lower respiratory infections (LRIs) and atopic sensitization have
been identified as independent risk factors for asthma. OBJECTIVE: The nature of potential …
been identified as independent risk factors for asthma. OBJECTIVE: The nature of potential …