A large body of experimental evidence supports the hypothesis that T‐helper 2 (Th2) cytokines
orchestrate allergic airway inflammation in animal models. However, human asthma is …

Chronic obstructive pulmonary disease (COPD) is a common, complex, and heterogeneous
disorder that is responsible for substantial and growing morbidity, mortality, and health-care …

With novel therapies in development, there is an opportunity to consider asthma remission
as a treatment goal. In this Rostrum, we present a generalized framework for clinical and …

Rationale: T-helper type 2 (Th2) inflammation, mediated by IL-4, IL-5, and IL-13, is considered
the central molecular mechanism underlying asthma, and Th2 cytokines are emerging …

Background Acute exacerbations adversely affect patients with chronic obstructive pulmonary
disease (COPD). Macrolide antibiotics benefit patients with a variety of inflammatory …

… We found that serpinB2 levels in bronchoalveaolar lavage fluid were below the lower limit
of detection (50 pg/ml) in all of the 13 healthy control subjects but were detectable in 13 of 27 …

Respiratory surfaces are exposed to billions of particulates and pathogens daily. A protective
mucus barrier traps and eliminates them through mucociliary clearance (MCC) 1 , 2 . …

BACKGROUND: Eosinophilic airway inflammation is heterogeneous in asthmatic patients.
We recently described a distinct subtype of asthma defined by the expression of genes …

Background Currently, the diagnosis of chronic obstructive pulmonary disease (COPD)
requires a ratio of forced expiratory volume in 1 second (FEV 1 ) to forced vital capacity (FVC) of …

Rationale: Coronavirus disease (COVID-19) is caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2). ACE2 (angiotensin-converting enzyme 2), and TMPRSS2 (…