User profiles for P. J. Norman

Paul Norman

- Verified email at ucdenver.edu - Cited by 9894

Patrick Norman

- Verified email at strath.ac.uk - Cited by 2225

Human-specific evolution of killer cell immunoglobulin-like receptor recognition of major histocompatibility complex class I molecules

P Parham, PJ Norman… - … Transactions of the …, 2012 - royalsocietypublishing.org
In placental mammals, natural killer (NK) cells are a population of lymphocytes that make
unique contributions to immune defence and reproduction, functions essential for survival of …

Propulsion drive models for full electric marine propulsion systems

…, JD Schuddebeurs, PJ Norman… - IEEE Transactions …, 2009 - ieeexplore.ieee.org
Integrated full electric propulsion systems are being introduced across both civil and military
marine sectors. Standard power system analysis packages cover electrical and …

Deciphering the killer‐cell immunoglobulin‐like receptor system at super‐resolution for natural killer and T‐cell biology

V Béziat, HG Hilton, PJ Norman, JA Traherne - Immunology, 2017 - Wiley Online Library
Killer‐cell immunoglobulin‐like receptors ( KIR s) are components of two fundamental
biological systems essential for human health and survival. First, they contribute to host immune …

Genetic analyses of diverse populations improves discovery for complex traits

…, DY Lin, A Moreno-Estrada, G Nadkarni, PJ Norman… - Nature, 2019 - nature.com
Genome-wide association studies (GWAS) have laid the foundation for investigations into the
biology of complex traits, drug development and clinical guidelines. However, the majority …

The shaping of modern human immune systems by multiregional admixture with archaic humans

…, S Tavoularis, AM Little, RE Green, PJ Norman… - Science, 2011 - science.org
Whole genome comparisons identified introgression from archaic to modern humans. Our
analysis of highly polymorphic human leukocyte antigen (HLA) class I, vital immune system …

Genomic evidence for the Pleistocene and recent population history of Native Americans

…, J Cybulski, B Petzelt, J Mitchell, R Worl, PJ Norman… - Science, 2015 - science.org
INTRODUCTION The consensus view on the peopling of the Americas is that ancestors of
modern Native Americans entered the Americas from Siberia via the Bering Land Bridge and …

Genetic and environmental determinants of human NK cell diversity revealed by mass cytometry

…, H Maecker, GE Swan, MM Davis, PJ Norman… - Science translational …, 2013 - science.org
Natural killer (NK) cells play critical roles in immune defense and reproduction, yet remain
the most poorly understood major lymphocyte population. Because their activation is …

Hunter-gatherer genomic diversity suggests a southern African origin for modern humans

…, D Comas, KK Kidd, PJ Norman… - Proceedings of the …, 2011 - National Acad Sciences
Africa is inferred to be the continent of origin for all modern human populations, but the details
of human prehistory and evolution in Africa remain largely obscure owing to the complex …

Synergistic polymorphism at two positions distal to the ligand-binding site makes KIR2DL2 a stronger receptor for HLA-C than KIR2DL3

AK Moesta, PJ Norman, M Yawata… - The Journal of …, 2008 - journals.aai.org
Interactions between HLA-C ligands and inhibitory killer cell Ig-like receptors (KIR) control
the development and response of human NK cells. This regulatory mechanism is usually …

[HTML][HTML] Reconstructing the population genetic history of the Caribbean

…, K Sandoval, S Acevedo-Acevedo, PJ Norman… - PLoS …, 2013 - journals.plos.org
The Caribbean basin is home to some of the most complex interactions in recent history
among previously diverged human populations. Here, we investigate the population genetic …