User profiles for P. L. Hedley

Paula Louise Hedley

Statens Serum Institut
Verified email at ssi.dk
Cited by 4122

The genetic basis of long QT and short QT syndromes: a mutation update

PL Hedley, P Jørgensen, S Schlamowitz… - Human …, 2009 - Wiley Online Library
Long QT and short QT syndromes (LQTS and SQTS) are cardiac repolarization abnormalities
that are characterized by length perturbations of the QT interval as measured on …

The genetic basis of Brugada syndrome: a mutation update

PL Hedley, P Jørgensen, S Schlamowitz… - Human …, 2009 - Wiley Online Library
Brugada syndrome (BrS) is a condition characterized by a distinct ST‐segment elevation in
the right precordial leads of the electrocardiogram and, clinically, by an increased risk of …

[PDF][PDF] Mutations in calmodulin cause ventricular tachycardia and sudden cardiac death

…, ER Behr, LL Hildebrandt, J Lund, PL Hedley… - The American Journal of …, 2012 - cell.com
Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a devastating inherited
disorder characterized by episodic syncope and/or sudden cardiac arrest during exercise or …

Danish premature birth rates during the COVID-19 lockdown

G Hedermann, PL Hedley, M Bækvad-Hansen… - Archives of Disease in …, 2021 - fn.bmj.com
To explore the impact of COVID-19 lockdown on premature birth rates in Denmark, a nationwide
register-based prevalence proportion study was conducted on all 31 180 live singleton …

[HTML][HTML] The role of leptin in fetal growth during pre-eclampsia

VE de Knegt, PL Hedley, JK Kanters… - International Journal of …, 2021 - mdpi.com
Leptin is secreted by the placenta and has a multi-facetted role in the regulation of functions
related to pregnancy. Metabolic disorders and insufficient homeostatic compensatory …

Increased risk of preterm delivery and pre‐eclampsia in women with polycystic ovary syndrome and hyperandrogenaemia

…, J Grinsted, SO Larsen, PL Hedley… - … Journal of Obstetrics …, 2014 - Wiley Online Library
Objective To study the risk of adverse pregnancy outcomes in women with polycystic ovary
syndrome ( PCOS ), and to examine the role of hyperandrogenaemia. Design Cohort study. …

High Prevalence of Long QT Syndrome–Associated SCN5A Variants in Patients With Early-Onset Lone Atrial Fibrillation

…, N Nielsen, JB Nielsen, PL Hedley… - Circulation …, 2012 - Am Heart Assoc
… We also compared the 2 populations regarding the proportion of previously published
LQTS-associated variants, as reported in a recent comprehensive review by Hedley et al 27 and …

Leptin, adiponectin, and their ratio as markers of insulin resistance and cardiometabolic risk in childhood obesity

…, MAV Lund, U Lausten‐Thomsen, PL Hedley… - Pediatric …, 2020 - Wiley Online Library
Background It is imperative to develop markers for risk stratification and detection of
cardiometabolic comorbidities in children with obesity. The adipokines leptin and adiponectin are …

[HTML][HTML] Preterm birth, stillbirth and early neonatal mortality during the Danish COVID-19 lockdown

PL Hedley, G Hedermann, CM Hagen… - European journal of …, 2022 - Springer
… Consequently, despite the strain COVID-19 is expected to place on health care resources
[32], the observed reduction of xPTB is unlikely to be driven by a change in obstetric policies, …

[HTML][HTML] Adipose expression of adipocytokines in women with polycystic ovary syndrome

PF Svendsen, M Christiansen, PL Hedley, L Nilas… - Fertility and sterility, 2012 - Elsevier
OBJECTIVE: To investigate the role of adipocytokines in the pathophysiology of polycystic
ovary syndrome (PCOS) by analyzing the messenger RNA (mRNA) expression and plasma …