The International Agency for Research on Cancer (IARC) and the US National Cancer Institute
(NCI) have initiated a series of cancer-focused seminars [Scelo G, Hofmann JN, Banks …

Although CDKN2A is the most frequent high-risk melanoma susceptibility gene, the
underlying genetic factors for most melanoma-prone families remain unknown. Using whole-exome …

The DNA repair pathways help to maintain genomic integrity and therefore genetic variation
in the pathways could affect the propensity to develop cancer. Selected germline single …

… This new ICH guideline contains best practice recommendations for in vitro ion channel
and human induced pluripotent stem cell assays to enable use as follow-up studies in place of …

The genetic regulation of the human epigenome is not fully appreciated. Here we describe
the effects of genetic variants on the DNA methylome in human lung based on methylation-…

A number of epigenetic alterations occur in both the virus and host cellular genomes during
human papillomavirus (HPV)-associated carcinogenesis, and investigations of such …

Cytochrome P450 2D6 (CYP2D6) is responsible for the metabolism of up to 20% of small-molecule
drugs and therefore, may impact the safety and efficacy of medicines in broad …

Anillin is an actin-binding protein that can bind septins and is a component of the cytokinetic
ring. We assessed the anillin expression in 7,579 human tissue samples and cell lines by …

Septins are an evolutionarily conserved family of GTPases with diverse functions including
roles in cytokinesis that have been implicated in neoplasia. To address the potential role of …

The chromosome 9p21 region has been implicated in the pathogenesis of multiple cancers.
We analyzed 9p21 single nucleotide polymorphisms (SNPs) from eight genome-wide …