The aryl hydrocarbon (dioxin) receptor (AhR) has been studied for several decades largely
because of its critical role in xenobiotic-induced toxicity and carcinogenesis. Albeit this is a …

Traditionally considered as a critical intermediate in the toxic and carcinogenic response to
dioxin (2,3,7,8-tetrachlorodibenzo-p-dioxin, TCDD), the Aryl hydrocarbon/Dioxin receptor (…

The aryl hydrocarbon receptor (AhR) is well-known for its major contributions to the cellular
responses against environmental toxins and carcinogens. Notably, AhR has also emerged …

To gain insight into the function of peroxisome proliferator-activated receptor (PPAR)
isoforms in rodents, we disrupted the ligand-binding domain of the α isoform of mouse PPAR (…

… 1 DM Hilbert and PM Fernandez-Salguero contributed equally to this … FERNANDEZ-SALGUERO
ET AL. … 6C) as previously described (Fernandez-Salguero et …

Gadd45a-null mice generated by gene targeting exhibited several of the phenotypes
characteristic of p53-deficient mice, including genomic instability, increased radiation …

We have analyzed the possible role of the aryl-hydrocarbon receptor (AHR) in the aging
process of mice using a homozygous null mouse (Ahr-/-) line as a model. We studied 52 male …

Resveratrol, a natural phytoalexin, has gained much interest on the basis of its potential
chemopreventive activity against human cancer. In this work, using the human breast cancer cell …

… Additional support for a developmental role for the AhR is the high incidence of neonatal
mortality observed in offspring from AhR transgenic mice (Fernandez-Salguero et al., 1995). …

Resveratrol is a polyphenol found at high concentrations in grapes and red wine with
reported anticarcinogenic effects. We studied the molecular mechanism of resveratrol‐induced …