[HTML][HTML] Diabetic cardiovascular disease induced by oxidative stress

…, H Suzuki, K Toyama, JM Spin, PS Tsao - International journal of …, 2015 - mdpi.com
… The Tsao laboratory is supported by research grants from the NIH (1R01HL105299 and
1R011HL122939) and Veterans Administration (1I01BX002641)… Tsao amended the manuscript. …

Role of endothelial dysfunction in the pathogenesis of reperfusion injury after myocardial ischemia

AM Lefer, PS Tsao, DJ Lefer, XL Ma - The FASEB journal, 1991 - Wiley Online Library
Endothelial dysfunction occurs after myocardial ischemia and reperfusion characterized by
a marked reduction in endothelium‐dependent relaxation (EDR) due to reduced release or …

Circulating markers of abdominal aortic aneurysm presence and progression

J Golledge, PS Tsao, RL Dalman, PE Norman - Circulation, 2008 - Am Heart Assoc
Given the potentially large number of markers that may have been investigated, we carried
out a staged search strategy. First, we performed a general search to identify biomarkers that …

Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

…, YV Sun, K Cho, JM Gaziano, PWF Wilson, PS Tsao… - Nature …, 2018 - nature.com
High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease.
We report the largest genetic association study of blood pressure traits (systolic, diastolic …

Asymmetric dimethylarginine (ADMA): a novel risk factor for endothelial dysfunction: its role in hypercholesterolemia

RH Böger, SM Bode-Böger, A Szuba, PS Tsao… - Circulation, 1998 - Am Heart Assoc
Background—Asymmetric dimethylarginine (ADMA) is an endogenous competitive inhibitor
of nitric oxide (NO) synthase. Because endothelial NO elaboration is impaired in …

Nicotine stimulates angiogenesis and promotes tumor growth and atherosclerosis

…, JJ Jang, M Weis, A Pathak, S Kaji, RS Hu, PS Tsao… - Nature medicine, 2001 - nature.com
We provide anatomic and functional evidence that nicotine induces angiogenesis. We also
show that nicotine accelerates the growth of tumor and atheroma in association with …

Impaired nitric oxide synthase pathway in diabetes mellitus: role of asymmetric dimethylarginine and dimethylarginine dimethylaminohydrolase

KY Lin, A Ito, T Asagami, PS Tsao, S Adimoolam… - Circulation, 2002 - Am Heart Assoc
Background— An endogenous inhibitor of nitric oxide synthase, asymmetric dimethylarginine
(ADMA), is elevated in patients with type 2 diabetes mellitus (DM). This study explored the …

Novel mechanism for endothelial dysfunction: dysregulation of dimethylarginine dimethylaminohydrolase

A Ito, PS Tsao, S Adimoolam, M Kimoto, T Ogawa… - Circulation, 1999 - Am Heart Assoc
Background—Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of nitric
oxide synthase (NOS). Plasma levels of ADMA are elevated in individuals with …

Homocysteine impairs the nitric oxide synthase pathway: role of asymmetric dimethylarginine

MC Stühlinger, PS Tsao, JH Her, M Kimoto… - Circulation, 2001 - Am Heart Assoc
Background Hyperhomocysteinemia is a putative risk factor for cardiovascular disease,
which also impairs endothelium-dependent vasodilatation. A number of other risk factors for …

Discovery of 318 new risk loci for type 2 diabetes and related vascular outcomes among 1.4 million participants in a multi-ancestry meta-analysis

…, DJ Rader, SM Damrauer, CJ O'Donnell, PS Tsao… - Nature …, 2020 - nature.com
We investigated type 2 diabetes (T2D) genetic susceptibility via multi-ancestry meta-analysis
of 228,499 cases and 1,178,783 controls in the Million Veteran Program (MVP), DIAMANTE…