The solubility of proteins is an essential requirement for their function. Nevertheless, these
ubiquitous molecules can undergo aberrant aggregation when the protein homeostasis …

Conspectus Protein domains can fold into stable tertiary structures while they are synthesized
by the ribosome in a process known as cotranslational folding. If a protein does not fold …

Aging has been associated with a progressive decline of proteostasis, but how this process
affects proteome composition remains largely unexplored. Here, we profiled more than 5,000 …

… Our interest is in whether the overall distribution of p-values is significantly skewed below
p=0.05. For this purpose, the multiple hypothesis corrections previously described are …

… Because of the high number of data and hypotheses tested in this study, we adjusted the
P values to reduce the false discovery rate (FDR). Specifically, for Figs. 1 and 3 to 5 and figs. …

… To correct for multiple hypotheses, we adjusted these P values to the Benjamini–Hochberg-derived
Q values calculated separately for the enrichment testing on the coaggregators and …

A question of fundamental importance concerning protein folding in vivo is whether the kinetics
of translation or the thermodynamics of the ribosome nascent chain (RNC) complex is the …

… A p < 0.05 was considered statistically significant in all analyses. All statistical analyses
were performed using STATA version 13 software (StataCorp, College Station, TX). …

… Coloring of the table encodes −log(p), with p being the Fisher’s exact test P value for the
overlap of the two modules. The table indicates that most of the modules of the VC dataset have …

… In general, we had 10 P values because we analyzed 10 microarray studies separately,
although in some cases there were fewer than 10 P values because some genes are …