Prodrugs are an established concept to overcome barriers to a drug’s usefulness. In Germany,
about 6.9% of all marketed medicines can be classified as prodrugs, an estimate based …

Hardmetals or cemented carbides (sometimes less accurately called sin tered carbides) are
composite materials with one or more hard but rela tively brittle components and a ductile …

… P and P=0, respectively, and a, b, c are constants independent of porosity, but dependent
on the shape and size of the average pore as well as on the properties of the investigated …

An overview of the metallurgical reactions during the vacuum sintering process of powder
mixtures for the manufacture of cermets is presented. The relatively complex phase reactions …

To date, there are no effective targeted pan-KRAS therapies. In-depth characterization of BI-3406
activity and identification of MEK inhibitors as effective combination partners provide …

Targeting subunits of BAF/PBAF chromatin remodeling complexes has been proposed as an
approach to exploit cancer vulnerabilities. Here, we develop proteolysis targeting chimera (…

… In samples of the series Ti(C x N 1−x ) 0.82 a discontinuity in the C p vs. T curves could be
detected at 700–820 C depending on the [C] ([C] + [N]) ratio, indicative of a phase transition. …

The thermal expansion values of the fee phases Ti(C x N 1−x ), Zr(C x N 1−x ) and Hf(C x N
1−x with [C+N]/[Me] ∼1 and TiN 1−x with [N]/[Ti] = 1.0 to 0.67 were determined from lattice …

… This paper is a condensed and partly updated version of a book chapter: “Introduction to
Hardmetals — History of Hardmetals” by P. Ettmayer, H. Kolaska and HM Ortner in the book: “…

In high and low pressure experiments in the Mo-N system the solidus line (α + L) and the
composition and temperature of the eutectic (L = α-Mo + γ-Mo 2 N) have been determined. Mo …