Chemical compounds that interfere with microtubules such as the vinca alkaloids and taxanes
are important chemotherapeutic agents for the treatment of cancer. As our knowledge of …

The regulation of p53 functions is tightly controlled through several mechanisms including
p53 transcription and translation, protein stability, post-translational modifications, and …

Recent studies have shown that the microtubule-stabilizing drug paclitaxel, which is commonly
used for the treatment of prostate cancer, inhibits signaling from the androgen receptor by …

The heterogeneity of exosomal populations has hindered our understanding of their biogenesis,
molecular composition, biodistribution and functions. By employing asymmetric flow field…

Acquired resistance to paclitaxel can be mediated by P-glycoprotein or by alterations
involving tubulin. We report two paclitaxel-resistant sublines derived from 1A9 human ovarian …

… Lanes P contain the polymerized form of tubulin and lanes S contain the depolymerized
soluble form of tubulin. The percent- … This analysis revealed a significant decrease (p …

letters to nature Page 1 letters to nature magnetoresistive component in CMR materials
arising at grain boundaries at high temperatures. Our highly symmetric Wheatstone-bridge …

Epothilones A and B, natural products with minimal structural analogy to taxoids, have effects
similar to those of paclitaxel (Taxol®) in cultured cells and on microtubule protein, but differ …

… The percent of polymerized tubulin (% P) was determined by dividing the densitometric value
of polymerized tubulin by the total tubulin content (the sum of P plus S). The results shown …

Prostate cancer progression requires active androgen receptor (AR) signaling which occurs
following translocation of AR from the cytoplasm to the nucleus. Chemotherapy with taxanes …