Obesity is heritable and predisposes to many diseases. To understand the genetic basis of
obesity better, here we conduct a genome-wide association study and Metabochip meta-…

We have previously linked families with autosomal-dominant, late-onset parkinsonism to
chromosome 12p11.2-q13.1 (PARK8). By high-resolution recombination mapping and …

Educational attainment is strongly influenced by social and other environmental factors, but
genetic factors are estimated to account for at least 20% of the variation across individuals 1. …

Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic
outcomes, independent of overall adiposity. To increase our understanding of the genetic …

… We identified SNPs at 41 new breast cancer susceptibility loci at genome-wide significance
(P < 5 × 10 −8 ). Further analyses suggest that more than 1,000 additional loci are involved …

… The results of the analysis are shown as log-transformed P values color coded to match
the transcript of interest. Notably, genotypes across this locus are associated with MAPT (pink) …

A genome-wide association study (GWAS) of educational attainment was conducted in a
discovery sample of 101,069 individuals and a replication sample of 25,490. Three …

… Removing these restrictions turned out not to alter our conclusions, with P values changing
only minimally. For the analysis of the LD pattern and haplotype block delineation, we used …

… In such circumstances each REV is in a state of partial equilibrium; that is, in thermal and
mechanical equilibrium at some temperature T and pressure p, but generally in disequilibrium …

… We found that the mutations in the CCD2 domain (p.690-713del and p.Glu696Lys) rendered
TBK1 unable to bind … The kinase activities of overexpressed TBK1 p.690-713del and …