Background and Purpose— This scientific statement provides an overview of the evidence
on vascular contributions to cognitive impairment and dementia. Vascular contributions to …

… No comprehensive and persuasive explanation has been offered so far for this
discrepancy, but a role for APOE4 in the toxicity of both Aβ and p-tau has been suggested 67 . …

… Nilsson contributed to the writing of the manuscript. All the authors have read the final …
Mogyorosy, Z.; Smith, P. The Main Methodological Issues in Costing Health Care Services: A …

Recommendations about therapy for hypertension are here preceded by some considerations
on the strength of available evidence on the benefits associated with antihypertensive …

… 13 organ systems, as described in (P), and the fraction of all transcripts (FPKM) encoded by
these elevated genes for each of these organ systems. (P) An analysis of major GO terms for …

… We repeated the meta-analysis, combining evidence for association solely on the basis of
the P values. Specifically, for each study, we converted the two-sided P value to a z statistic …

New strategies for prevention and treatment of type 2 diabetes (T2D) require improved insight
into disease etiology. We analyzed 386,731 common single-nucleotide polymorphisms (…

By combining genome-wide association data from 8,130 individuals with type 2 diabetes (T2D)
and 38,987 controls of European descent and following up previously unidentified meta-…

… cutoff in an individual patient yields a significant (P < 0.001) difference in overall survival. …
P value calculated for each gene and cancer. In each case, a significant separation (P < 0.001) …

Blood pressure is a heritable trait 1 influenced by several biological pathways and responsive
to environmental stimuli. Over one billion people worldwide have hypertension (≥140 mm …