INTRODUCTION Brain disorders may exhibit shared symptoms and substantial epidemiological
comorbidity, inciting debate about their etiologic overlap. However, detailed study of …

… Palta and Schneider contributed equally to this work. The authors declare no conflicts of
interest. Portions of this research were presented at the American Diabetes Association 72nd …

Population isolates such as those in Finland benefit genetic research because deleterious
alleles are often concentrated on a small number of low-frequency variants (0.1% ≤ minor …

… mutations had more than expected direct interconnections (P = 0.008), which was consistent
with more overall connectivity to synaptic proteins as a whole (P = 0.005). b, Overlap of …

Population isolates such as Finland provide benefits in genetic studies because the allelic
spectrum of damaging alleles in any gene is often concentrated on a small number of low-…

Background Although 10 000 steps per day is widely promoted to have health benefits, there
is little evidence to support this recommendation. We aimed to determine the association …

Migraine is a debilitating neurological disorder affecting around one in seven people worldwide,
but its molecular mechanisms remain poorly understood. There is some debate about …

Obesity has become a major worldwide challenge to public health, owing to an interaction
between the Western ‘obesogenic’ environment and a strong genetic contribution 1 . Recent …

Migraine is the most common brain disorder, affecting approximately 14% of the adult
population, but its molecular mechanisms are poorly understood. We report the results of a meta-…

Exome sequencing studies in complex diseases are challenged by the allelic heterogeneity,
large number and modest effect sizes of associated variants on disease risk and the …