Metagenomic analysis of milk of healthy and mastitis-suffering women

…, M Manrique, P Pareja-Tobes… - Journal of Human …, 2015 - journals.sagepub.com
Background: Some studies have been conducted to assess the composition of the bacterial
communities inhabiting human milk, but they did not evaluate the presence of other …

[HTML][HTML] BG7: a new approach for bacterial genome annotation designed for next generation sequencing data

P Pareja-Tobes, M Manrique, E Pareja-Tobes… - PLoS …, 2012 - journals.plos.org
BG7 is a new system for de novo bacterial, archaeal and viral genome annotation based on
a new approach specifically designed for annotating genomes sequenced with next …

[HTML][HTML] ExtraTrain: a database of Extragenic regions and Transcriptional information in prokaryotic organisms

…, P Pareja-Tobes, M Manrique, E Pareja-Tobes… - BMC microbiology, 2006 - Springer
Background Transcriptional regulation processes are the principal mechanisms of adaptation
in prokaryotes. In these processes, the regulatory proteins and the regulatory DNA signals …

Bio4j: a high-performance cloud-enabled graph-based data platform

P Pareja-Tobes, R Tobes, M Manrique, E Pareja… - BioRxiv, 2015 - biorxiv.org
Background Next Generation Sequencing and other high-throughput technologies have
brought a revolution to the bioinformatics landscape, by offering sheer amounts of data about …

[HTML][HTML] Important biological information uncovered in previously unaligned reads from chromatin immunoprecipitation experiments (ChIP-Seq)

…, MK Mejia-Guerra, A Yilmaz, P Pareja-Tobes… - Scientific reports, 2015 - nature.com
Establishing the architecture of gene regulatory networks (GRNs) relies on chromatin
immunoprecipitation followed by massively parallel sequencing (ChIP-Seq) methods that provide …

Gene calling and bacterial genome annotation with BG7

…, P Pareja-Tobes, M Manrique, E Pareja-Tobes… - … : Methods and Protocols, 2015 - Springer
New massive sequencing technologies are providing many bacterial genome sequences
from diverse taxa but a refined annotation of these genomes is crucial for obtaining scientific …

Bio4J: An Open source biological data integration platform.

P Pareja-Tobes, E Pareja-Tobes, M Manrique, E Pareja… - IWBBIO, 2013 - iwbbio.ugr.es
Today’s biology involves many times the use of different omics approaches, in particular, data
and information from genomes and proteins are frequently difficult to integrate. In order to …

Escherichia coli EHEC Germany outbreak preliminary functional annotation using BG7 system

M Manrique, P Pareja-Tobes, E Pareja-Tobes… - Nature …, 2011 - nature.com
We have annotated the European outbreak E. coli EHEC genome sequenced by BGI (6-2-2011)
and assembled with MIRA by Nick Loman (6-2-2011 ). Our system BG7, Bacterial …

MG7: Configurable and scalable 16S metagenomics data analysis

…, P Pareja-Tobes, E Pareja, R Tobes, E Pareja-Tobes - BioRxiv, 2015 - biorxiv.org
p is a coefficient fixed by the user to define the bitscore required, eg if p = 0.9 and S = 700
the required bitscore threshold would be 630. Once we have the definitive HSPs selected, we …

Search spaces representation in optimization problems

P Pareja-Tobes, D Pelta, A Sancho-Royo… - Expert Systems with …, 2008 - Elsevier
We present formally a search space representation method in combinatorial optimization
problems, as well as a tool for the visualization of the trajectories of heuristic algorithms based …